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| | PTP1B-IN-2 Basic information |
| Product Name: | PTP1B-IN-2 | | Synonyms: | PTP1B-IN-2;MDK3465;PTP1B inhibitor 2;PTP1B-IN-2;PTP1B INHIBITOR 2;Inhibitor,PTP-1B-IN-2,inhibit,PTP1BIN2,Phosphatase,PTP1B IN 2;Benzoic acid, 5-[[[4-[(2-methoxy-2-oxoethyl)(methylsulfonyl)amino]phenyl]methyl][(phenylmethyl)sulfonyl]amino]-2-[(4-methylphenyl)methoxy]-, methyl ester | | CAS: | 1919853-46-5 | | MF: | C34H36N2O9S2 | | MW: | 680.79 | | EINECS: | | | Product Categories: | | | Mol File: | 1919853-46-5.mol |  |
| | PTP1B-IN-2 Chemical Properties |
| Boiling point | 813.4±75.0 °C(Predicted) | | density | 1.350±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: insol; PBS (pH 7.2): insol | | form | A solid | | pka | -3.81±0.50(Predicted) |
| | PTP1B-IN-2 Usage And Synthesis |
| Biological Activity | PTP1B-IN-2 (MDK3465, Ptp1B-In-2, Compound P6) is a potent and selective inhibitor of protein tyrosine phosphatase-1B (PTP1B) with IC50 of 50 nM. It enhances insulin-mediated phosphorylation of insulin receptor beta (IRβ) and insulin-stimulated glucose uptake. | | in vitro | PTP1B-IN-2 displays more than 40-fold selectivity for PTP1B over SHP-2 and LAR and 15-fold higher selectivity for PTP1B over the highly homologous TCPTP. | | target | | Target | Value | PTP1B
(Cell-free assay) | 50 nM |
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| | PTP1B-IN-2 Preparation Products And Raw materials |
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