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Product Name:GSK-LSD1 Dihydrochloride CAS:2102933-95-7 Purity:80RMB/5mg Package:>98%
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| GSK-LSD1 Dihydrochloride Basic information |
Product Name: | GSK-LSD1 Dihydrochloride | Synonyms: | GSK LSD1 dihydrochloride,Monoamine Oxidase,GSK-LSD-1 dihydrochloride,Inhibitor,inhibit,GSK-LSD1,MAO,GSKLSD1 dihydrochloride,Histone Demethylase | CAS: | 2102933-95-7 | MF: | C14H21ClN2 | MW: | 252.79 | EINECS: | | Product Categories: | | Mol File: | 2102933-95-7.mol | ![GSK-LSD1 Dihydrochloride Structure](CAS/20210111/GIF/2102933-95-7.gif) |
| GSK-LSD1 Dihydrochloride Chemical Properties |
storage temp. | Store at -20°C | solubility | DMF: 1 mg/ml; DMSO: 25 mg/ml; Ethanol: 0.1 mg/ml; PBS (pH 7.2): 10 mg/ml | form | A crystalline solid |
| GSK-LSD1 Dihydrochloride Usage And Synthesis |
Description | Lysine-specific demethylase 1 (LSD1) belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs) and polyamine oxidase (PAO).1 LSD1 specifically demethylates mono- and dimethylated histone H3 lysine 4, resulting in transcriptional repression.2 It also controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS370).3 GSK-LSD1 is an irreversible, mechanism-based inhibitor of LSD1 (IC50 = 16 nM) that is >1,000-fold selective over the closely related FAD-utilizing enzymes LSD2, MAO-A, and MAO-B.4 GSK-LSD1 induces gene expression changes in various cancer cell lines, inhibiting their proliferation (EC50s <5 nM).4 See the Structural Genomics Consortium (SGC) website for more information. | storage | Store at +4°C | References | 1. Shi, Y., Lan, F., Matson, C., et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 Cell 119(7),941-953(2004). 2. Forneris, F., Binda, C., Vanoni, M.A., et al. Human histone demethylase LSD1 reads the histone code J. Biol. Chem. 280(50),41360-41365(2005). 3. Huang, J., Sengupta, R., Espejo, A.B., et al. p53 is regulated by the lysine demethylase LSD1 Nature 449,105-108(2007). 4. Epigenetics probes collection ,(2014). |
| GSK-LSD1 Dihydrochloride Preparation Products And Raw materials |
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