Company Name: |
DC Chemicals
|
Tel: |
021-58447131 13564518121 |
Email: |
sales@dcchemicals.com |
Products Intro: |
Product Name:AX-024 free base CAS:1370544-73-2 Purity:98% HPLC Package:100mg,250mg,1g
|
|
| AX-024 hcl Basic information |
Product Name: | AX-024 hcl | Synonyms: | AX-024 hcl;AX 024;AX024;CS-2619;Pyrrolidine, 1-[[4-(4-fluorophenyl)-6-methoxy-2H-1-benzopyran-3-yl]methyl]-;1-((4-(4-FLUOROPHENYL)-6-METHOXY-2H-CHROMEN-3-YL)METHYL)PYRROLIDINE | CAS: | 1370544-73-2 | MF: | C21H22FNO2 | MW: | 339.4 | EINECS: | | Product Categories: | | Mol File: | 1370544-73-2.mol | |
| AX-024 hcl Chemical Properties |
Boiling point | 452.0±45.0 °C(Predicted) | density | 1.201±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO:35.0(Max Conc. mg/mL);103.12(Max Conc. mM) Ethanol:100.0(Max Conc. mg/mL);294.63(Max Conc. mM) | pka | 9.26±0.20(Predicted) |
| AX-024 hcl Usage And Synthesis |
Description | AX-024 is an inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation. AX-024 modulates cell signaling by targeting SH3 domains and has low-acute toxicity and high potency and selectivity in the inhibition of the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A. | Uses | AX-024, is >10,000-fold more potent than the AX-000 hit in terms of inhibition of TCR-triggered T cell proliferation. It is a cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A. | in vitro | AX-024 reduces T cell proliferation upon weak T cell receptor (TCR) stimulation but neither significantly affects phosphorylation of Zap70 (ζ chain of T cell receptor–associated protein kinase 70) nor interacts directly with Nck1-SH3. AX-024 is likely not involved in modulating the Nck/TCR interaction but probably has other targets in T cells. An array of biophysical techniques did not detect a direct interaction between AX-024 and Nck-SH3.1 in vitro._x000D_
_x000D_
Reference: J Biol Chem. 2020 Jun 5;295(23):7849-7864. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278359/#B11 | target | AX-024 is an inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. |
| AX-024 hcl Preparation Products And Raw materials |
|