| Company Name: |
Shaanxi Xinyan Bomei Biotechnology Co., Ltd.
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| Tel: |
029-86217788 13892832556 |
| Email: |
2440688701@qq.com |
| Products Intro: |
Product Name:Sulfo DBCO-PEG4-amine
CAS:2055198-05-3
Purity:95% HPLC Package:1g;5g;10g;25g;100g;1kg
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| Company Name: |
Guangzhou Younan Technology Co., Ltd
|
| Tel: |
020-82000279 18988968278 |
| Email: |
YN_research@163.com |
| Products Intro: |
Product Name:Sulfo dbco-peg4-amine
CAS:2055198-05-3
Purity:>95% Package:5mg;10mg;25mg;50mg;100mg
|
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| | Sulfo DBCO-PEG4-amine Basic information |
| Product Name: | Sulfo DBCO-PEG4-amine | | Synonyms: | 12,15,18,21-Tetraoxa-4,8-diazatricosane-6-sulfonic acid, 23-amino-1-(11,12-dihydrodibenz[b,f]azocin-5(6H)-yl)-1,5,9-trioxo-;Sulfo DBCO-PEG4-NH2 | | CAS: | 2055198-05-3 | | MF: | C32H42N4O10S | | MW: | 674.77 | | EINECS: | | | Product Categories: | | | Mol File: | 2055198-05-3.mol |  |
| | Sulfo DBCO-PEG4-amine Chemical Properties |
| density | 1.36±0.1 g/cm3(Predicted) | | pka | 0.34±0.50(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | Sulfo DBCO-PEG4-amine Usage And Synthesis |
| Description | Sulfo DBCO-PEG4-Amine is a water-soluble carboxyl-reactive building block with extended PEG spacer arm. In the presence of of activators (e.g. EDC, or HATU), this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. The hydrophilic sulfonated spacer arm greatly improves water solubility of DBCO derivatized molecules and a provides a long and flexible connection. DBCO is commonly used for copper-free Click Chemistry reactions. | | Uses | Sulfo DBCO-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Sulfo DBCO-PEG4-amine Preparation Products And Raw materials |
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