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| | MOZ-IN-3 Basic information |
| Product Name: | MOZ-IN-3 | | Synonyms: | MOZ-IN-3;[1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide;MOZ-IN-3/WM-8014;WM-8014;WM 8014;WM8014;KAT6A INHIBITOR; KAT6B INHIBITOR;KAT6B inhibitor;KAT6A inhibitor;1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 3-(phenylsulfonyl)hydrazide;WM-8014,HAT,inhibit,Inhibitor,HATs,WM 8014,Histone Acetyltransferase,WM8014 | | CAS: | 2055397-18-5 | | MF: | C20H17FN2O3S | | MW: | 384.42 | | EINECS: | | | Product Categories: | | | Mol File: | 2055397-18-5.mol |  |
| | MOZ-IN-3 Chemical Properties |
| density | 1.307±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.1 mg/ml; DMSO: 33 mg/ml; Ethanol: 2 mg/ml | | form | A crystalline solid | | pka | 7.15±0.25(Predicted) |
| | MOZ-IN-3 Usage And Synthesis |
| Description | MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively). It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 μM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 μM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 μM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2. | | Uses | MOZ-IN-3 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B. | | storage | Store at -20°C |
| | MOZ-IN-3 Preparation Products And Raw materials |
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