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PENICILLIC ACID

PENICILLIC ACID Suppliers list
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Products Intro: Product Name:Penicillic acid, 99%
CAS:90-65-3
Purity:99% Package:25MG;5MG
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Products Intro: Product Name:Penicillic acid
CAS:90-65-3
Purity:99% Remarks:22927
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Products Intro: Product Name:Penicillic Acid
CAS:90-65-3
Purity:99% Package:25kg
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Products Intro: Product Name:Penicillic acid, 99% 25MG
CAS:90-65-3
Purity:99% Package:25MG
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Products Intro: Product Name:Penicillic Acid
CAS:90-65-3
Purity:98% by HPLC Package:10mg,25mg,50mg,100mg
PENICILLIC ACID Basic information
Product Name:PENICILLIC ACID
Synonyms:3-METHOXY-5-METHYL-4-OXO-2,5-HEXADIENOIC ACID;3-methoxy-5-methyl-4-oxo-5-hexadienoicacid;gamma-keto-beta-methoxy-delta-methylene-delta(supalpha)-hexenoicacid;kyselinapenicilova;pencillicacid;PENICILLIC ACID;3-methoxy-5-methyl-4-oxohexa-2,5-dienoic acid;PENICILLIC ACID 99%
CAS:90-65-3
MF:C8H10O4
MW:170.16
EINECS:202-008-1
Product Categories:antibiotic
Mol File:90-65-3.mol
PENICILLIC ACID Structure
PENICILLIC ACID Chemical Properties
Melting point 83-87 °C
Boiling point 219.79°C (rough estimate)
density 1.1456 (rough estimate)
refractive index 1.4425 (estimate)
storage temp. Store at 2-8
solubility DMSO: >10mg/mL
Merck 13,7163
CAS DataBase Reference90-65-3
Safety Information
Hazard Codes Xn,T
Risk Statements 36/37/38-20/21/22-22
Safety Statements 37/39-26-24/25
RIDADR 2811
RTECS MM2625000
HazardClass 6.1(b)
PackingGroup III
HS Code 29189900
ToxicityLD50 i.p. in mice: 90.00 mg/kg (Chan et al.)
MSDS Information
ProviderLanguage
ACROS English
PENICILLIC ACID Usage And Synthesis
Chemical Propertieswhite to light beige crystals or powder
UsesGram negative bacteria utilize N-acylated homoserine lactones to coordinate expression of virulence in response to the density of the surrounding bacterial population in a process termed quorum sensing. By interfering with this communication and thereby disrupting virulence expression, quorum sensing inhibitors are emerging as an alternative to the conventional ways of fighting bacterial infections. Penicillic acid is a mycotoxin produced from Penicillium species identified in molds on corn and other grains. At 80 μM, penicillic acid inhibits bacterial quorum sensing communication in P. aeruginosa by selectively repressing various virulence factor and other quorum sensing-regulated genes. It has been shown to inhibit Fas-mediated apoptosis at 100-200 μM by targeting caspase-8 activity in Burkitt’s lymphoma Raji cells.
Safety ProfilePoison by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification MethodsThe lactone (furanone, anhydrous) hydrolyses to the acid (3-methoxy-4-oxo-hexa-2,5-dienoic acid, hydrate). It crystallises from water as the monohydrate (acid), or from pet ether as the anhydrous (lactone) compound. The free acid is in equilibrium with the lactone. UV: max 221nm ( 12,500) in 0.02M KOH; 228nm ( 11,500) in 0.02M HCl [Raphael J Chem Soc 1508 1948]. [Beilstein 3 II 519, 3 III 1467.] It is a possible antineoplastic.
PENICILLIC ACID Preparation Products And Raw materials
Tag:PENICILLIC ACID(90-65-3) Related Product Information
Penicillin G sodium salt Penicillic acid trifluoroacetate 6-Aminopenicillanic acid Penicillic acid sodium Methoxyethene TRANS-2-HEXENOIC ACID 4-OXO-2-HEXENAL 2-Propenoic acid Crotonic acid Methoxyacetone 2-Methoxypropene TRANS-2-HEXEN-1-OL 3-METHYL-3-BUTEN-1-OL PENICILLIC ACID (E)-4-OXO-PENT-2-ENOIC ACID TRANS-2-PENTENOIC ACID TRANS-2-PENTEN-1-OL