| Company Name: |
Hu Bei Jiutian Bio-medical Technology CO.,Ltd |
| Tel: |
027-88013699 17354350817 |
| Email: |
Ryan@jiutian-bio.com |
| Products Intro: |
Product Name:Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-9,11-dichloro-17-hydroxy-, (11b)-
CAS:79-61-8
Purity:0.99 Package:25kg,50kg,180kg,200kg,250kg,1000kg,as your needs Remarks:as your needs
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| Company Name: |
MedChemexpress LLC
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| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:Dichlorisone acetate
CAS:79-61-8
Purity:50RMB/100mg Package:>98%
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| | DICHLORISONE ACETATE Basic information |
| Product Name: | DICHLORISONE ACETATE | | Synonyms: | 9ALPHA,11BETA-DICHLORO-17ALPHA,21-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE;1,4-PREGNADIEN-9-ALPHA, 11-BETA-DICHLORO-17,21-DIOL-3,20-DIONE 21-ACETATE;dichlorisone 21-acetate;9α,11β-Dichloro-17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate;21-Acetyloxy-9,11β-dichloro-17-hydroxypregna-1,4-diene-3,20-dione;Sch 5005;[2-[(9R,17R)-9,11-dichloro-17-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate;[2-[(9R,17R)-9,11-dichloro-17-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] ethanoate | | CAS: | 79-61-8 | | MF: | C23H28Cl2O5 | | MW: | 455.37 | | EINECS: | 201-213-3 | | Product Categories: | Inhibitors;DILODERM | | Mol File: | 79-61-8.mol |  |
| | DICHLORISONE ACETATE Chemical Properties |
| Melting point | 246-253 °C (decomp) | | Boiling point | 596.2±50.0 °C(Predicted) | | alpha | D25 +162° (dioxane) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 4.35 mg/mL (9.55 mM); Water: < 0.1 mg/mL (insoluble) | | pka | 11.94±0.70(Predicted) |
| | DICHLORISONE ACETATE Usage And Synthesis |
| Originator | Diloderm ,Schering,US,1960 | | Uses | antipruretic | | Definition | ChEBI: Dichlorisone is a corticosteroid hormone. | | Manufacturing Process | A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21-
acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous
hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture
is stirred for 2 hours and poured into ice water. The crude product is filtered
and washed with water to give 1.12 g of solid material, which is recrystallized
from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4-
pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.). | | Brand name | Diloderm (Schering). | | Therapeutic Function | Antipruritic, Antihistaminic, Appetite stimulant |
| | DICHLORISONE ACETATE Preparation Products And Raw materials |
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