ANTI-ANAPLASTIC LYMPHOMA KINASE

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ANTI-ANAPLASTIC LYMPHOMA KINASE Suppliers list
Company Name: Merck KGaA  
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Email: ordercn@merckgroup.com
Company Name: Guangzhou Kati Biotechnology Co., Ltd.  
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Company Name: Vision BioSystems  
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ANTI-ANAPLASTIC LYMPHOMA KINASE Basic information
Product Name:ANTI-ANAPLASTIC LYMPHOMA KINASE
Synonyms:Anti-WDR48 antibody produced in rabbit;ANTI-ANAPLASTIC LYMPHOMA KINASE (P80);ANTI-ANAPLASTIC LYMPHOMA KINASE;ANTI-HUMAN ALK PROTEIN;ANTI-HUMAN CD246;ANTI-NEURAL TYROSINE KINASE;ANTI-P80;Anti-WD repeat domain 48
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MW:0
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Mol File:Mol File
ANTI-ANAPLASTIC LYMPHOMA KINASE Structure
ANTI-ANAPLASTIC LYMPHOMA KINASE Chemical Properties
storage temp. -20°C
form buffered aqueous glycerol solution
biological sourcerabbit
Safety Information
WGK Germany WGK 1
Storage Class10 - Combustible liquids
MSDS Information
ANTI-ANAPLASTIC LYMPHOMA KINASE Usage And Synthesis
UsesAll Prestige Antibodies®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-WDR48 antibody produced in rabbit has been used in western blotting.
Biological ActivityUSP1-WDR48 (ubiquitin specific peptidase 1 - WD repe at domain 48) complex is involved in DNA damage responses. It is responsible for repair of interstrand DNA crosslinks through the Fanconi anemia pathway. It also reverses monoubiquitination of PCNA (proliferating cell nuclear antigen) and regulates translesion synthesis, a DNA damage tolerance response. This complex also participates in homologous recombination. USP1-WDR48 complex mainly controls nuclear protein ubiquitination. WDR48 also works as a tumor suppressor by enhancing PHLPP1 (PH domain leucine-rich repe at protein phosphatase 1) stability. The WDR48 - USP12 complex is responsible for deubiquitination of PHLPP1, which is needed for tumor suppressor function.
ANTI-ANAPLASTIC LYMPHOMA KINASE Preparation Products And Raw materials
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