N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide)

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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

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N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide) Basic information
Product Name:N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide)
Synonyms:N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide);Compound F0433-0067;Benzenesulfonamide, N,N'-1,4-phenylenebis[4-chloro-
CAS:2654-68-4
MF:C18H14Cl2N2O4S2
MW:457.35
EINECS:
Product Categories:
Mol File:2654-68-4.mol
N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide) Structure
N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide) Chemical Properties
Melting point 272 °C
Boiling point 615.8±65.0 °C(Predicted)
density 1.568±0.06 g/cm3(Predicted)
pka7.41±0.10(Predicted)
Safety Information
MSDS Information
N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide) Usage And Synthesis
UseshiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea[1].
References[1] Randy M Wadkins, et al. Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Mol Pharmacol. 2004 Jun;65(6):1336-43. DOI:10.1124/mol.65.6.1336
N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide) Preparation Products And Raw materials
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