Company Name: |
Sichuan Wei Keqi Biological Technology Co., Ltd.
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Tel: |
028-81700200 18116577057 |
Email: |
3003855609@qq.com |
Products Intro: |
Product Name:Trolline((±)-Trolline) CAS:1021950-79-7 Purity:HPLC>=98% Package:5mg;10mg;20mg;50mg;100mg;200mg;500mg;1g
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| 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Basic information |
Product Name: | 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE | Synonyms: | 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE;Trolline((±)-Trolline);Trolline;Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-8,9-dihydroxy-;Oleracein E;Trolline((±)-Trolline) | CAS: | 1021950-79-7 | MF: | C12H13NO3 | MW: | 219.24 | EINECS: | | Product Categories: | | Mol File: | 1021950-79-7.mol | |
| 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Chemical Properties |
| 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Usage And Synthesis |
Description | Oleracein E is a a tetrahydroisoquinoline possessing potent antioxidant activity. Pretreatment with OE (10 μM, 2 h) decreased lactic acid dehydrogenase (LDH) release and the apoptosis rate in rotenone (5 μM, 24 h)-treated SH-SY5Y human neuroblastoma cells. Further mechanistic study indicated that OE reduced reactive oxygen species (ROS) levels, inhibited extracellular signal-regulated kinase (ERK) 1/2 phosphorylation, reduced rotenone-induced up-regulation of the proapoptotic protein Bax, and prevented cytochrome C release and caspase-3 activation. |
| 8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE Preparation Products And Raw materials |
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