- 2-Chloro-6-methylaniline
-
- $50.00 / 1KG
-
2024-01-02
- CAS:87-63-8
- Min. Order: 1KG
- Purity: 99
- Supply Ability: g-kg-tons,free sample is available
|
| | 2-Chloro-6-methylaniline Basic information |
| | 2-Chloro-6-methylaniline Chemical Properties |
| Melting point | 10-12 °C(lit.) | | Boiling point | 215 °C(lit.) | | density | 1.152 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.576(lit.) | | Fp | 210 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) | | form | Oil | | pka | 2.51±0.10(Predicted) | | color | Clear Colourless to Pale Purple | | Water Solubility | Immiscible | | BRN | 774624 | | InChIKey | WFNLHDJJZSJARK-UHFFFAOYSA-N | | CAS DataBase Reference | 87-63-8(CAS DataBase Reference) | | NIST Chemistry Reference | Benzenamine, 2-chloro-6-methyl-(87-63-8) | | EPA Substance Registry System | 6-Chloro-2-methylaniline (87-63-8) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-20/21/22 | | Safety Statements | 26-36-36/37/39 | | RIDADR | UN 3429 6.1/PG 3 | | WGK Germany | 3 | | RTECS | XU5100000 | | TSCA | Yes | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29214300 |
| | 2-Chloro-6-methylaniline Usage And Synthesis |
| Description | 2-chloro-6-methylaniline is an important organic synthesis intermediate widely applied to chemical pharmacy, pesticides, and organic synthesis. In the aspects of chemical pharmacy and pesticides, 2-chloro-6-methylaniline can be used as a reaction starting material to participate in the preparation processes of tyrosine kinase inhibitors dasatinib, indazole derivatives with anti-breast cancer activity, 2-methyl-6-chlorophenyl sulfonylurea derivatives with bacteriostatic activity and the like; in the aspect of organic synthesis, 2-chloro-6-methylaniline can introduce chemical groups such as hydrazine, nitro, cyano, halogen (F, Cl, Br), and the like into an aromatic ring through diazotization reaction, thereby participating in wide chemical reactions.
| | Chemical Properties | clear yellow to red-brown liquid | | Chemical Properties | The chloromethylanilines are colorless or
white crystalline solids or liquids, some have a mild
fishy odor. | | Uses | 2-Chloro-6-methylaniline is a substituted aniline used in the preparation of various pharmaceutical compounds. 2-Chloro-6-methylaniline showed inhibition of the polymerization of vinyl acetate. | | Preparation | A preparation method of 2-chloro-6-methylaniline takes 3-chloro-5-methyl-4-nitroaniline as a starting material, water as a solvent, and sulfuric acid as a reactant. Eliminates amino groups through diazotization reaction, reduces by hypophosphorous acid to obtain an intermediate, and finally takes iron powder as reducing nitro groups to prepare the 2-chloro-6-methylaniline through a one-pot reaction.
| | Potential Exposure | Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill
birds. It is marketed as pelleted bait for control of bird
populations. | | Shipping | UN2239 Chlorotoluidines, solid, Hazard Class:
6.1; Labels: 6.1-Poisonous materials. UN3429
Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1-
Poisonous materials | | Incompatibilities | Incompatible with oxidizers, strong
acids; chloroformates, and acid anhydrides, isocyanates,
aldehydes forming fire and explosive hazards. |
| | 2-Chloro-6-methylaniline Preparation Products And Raw materials |
|