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Phenylbutazone

Phenylbutazone, often referred to as "bute," is a nonsteroidal anti-inflammatory, antipyretic, and analgesic drug (NSAID) for the short-term treatment of pain and fever results from rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, and osteoarthritis. Phenylbutazone has been removed from the United States market due to the availability of newer drugs with less adverse effects. Phenylbutazone is a nonsteroidal anti-inflammatory drug (NSAID) effective in treating fever, pain, and inflammation in the body. As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes, including injury, menstrual cramps, arthritis and other musculoskeletal conditions.
Phenylbutazone Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Phenylbutazone
CAS:50-33-9
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Email: Candy@bj-chem.com
Products Intro: Product Name:Phenylbutazone
CAS:50-33-9
Purity:99% Package:1Kg;25kg/ Drum or as customer request
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:50-33-9
CAS:50-33-9
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: career henan chemical co
Tel: +86-371-86658258
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Products Intro: Product Name:Phenylbutazone
CAS:50-33-9
Purity:98% Package:1KG;1USD
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:Phenylbutazone
CAS:50-33-9
Purity:98% HPLC LCMS Package:10G;20G

Lastest Price from Phenylbutazone manufacturers

  • Phenylbutazone
  • US $1.00-1.00 / KG
  • 2020-05-12
  • CAS:50-33-9
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
  • Phenylbutazone
  • US $1.00-1.00 / KG
  • 2020-05-12
  • CAS:50-33-9
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
  • Phenylbutazone
  • US $0.00 / mg
  • 2020-05-11
  • CAS:50-33-9
  • Min. Order: 20mg
  • Purity: ≥98%(HPLC)
  • Supply Ability: 10 g
Phenylbutazone Basic information
Abstract Chemical Property Mechanism of action Pharmacokinetic Study Attention and Taboo Preparation Acute toxicity Flammability hazard properties Storage characteristics Extinguishing agent References
Product Name:Phenylbutazone
Synonyms:Benzone;Betazed;bizolin;Bizolin 200;bizolin200;Bunetzone;Busone;Buta phen
CAS:50-33-9
MF:C19H20N2O2
MW:308.37
EINECS:200-029-0
Product Categories:Heterocycles;Inhibitors;API;AZOLID;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:50-33-9.mol
Phenylbutazone Structure
Phenylbutazone Chemical Properties
Melting point 104-107 °C
Boiling point 448.76°C (rough estimate)
density 1.1591 (rough estimate)
refractive index 1.6140 (estimate)
storage temp. -20°C Freezer
solubility Practically insoluble in water, sparingly soluble in alcohol. It dissolves in alkaline solutions.
pka4.5(at 25℃)
form Powder
color White to almost white
Water Solubility <0.1 g/100 mL at 23.5 ºC
Merck 14,7277
BRN 290080
Stability:Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
InChIKeyVYMDGNCVAMGZFE-UHFFFAOYSA-N
CAS DataBase Reference50-33-9(CAS DataBase Reference)
NIST Chemistry ReferencePhenylbutazone(50-33-9)
EPA Substance Registry SystemPhenylbutazone (50-33-9)
Safety Information
Hazard Codes Xn,T,F
Risk Statements 36/37/38-20/21/22-42/43-45-36-11
Safety Statements 36/37/39-26-45-22-53-36/37-16
RIDADR 3249
WGK Germany 3
RTECS UQ8225000
TSCA Yes
HazardClass 6.1(b)
PackingGroup III
HS Code 29331990
Hazardous Substances Data50-33-9(Hazardous Substances Data)
ToxicityLD50 oral in rabbit: 781mg/kg
MSDS Information
ProviderLanguage
4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione English
ACROS English
ALFA English
Phenylbutazone Usage And Synthesis
AbstractPhenylbutazone, often referred to as "bute,"is a nonsteroidal  anti-inflammatory, antipyretic, and analgesic drug (NSAID) for the short-term treatment of pain and fever results from rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, and osteoarthritis.
Phenylbutazone has been removed from the United States market due to the availability of newer drugs with less adverse effects. Phenylbutazone is a nonsteroidal anti-inflammatory drug (NSAID) effective in treating fever, pain, and inflammation in the body. As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes, including injury, menstrual cramps, arthritis and other musculoskeletal conditions.
Chemical PropertyIt is soluble in acetone, chloroform or benzene freely; soluble in ethanol or ether; hardly soluble in water; soluble in sodium hydroxide solution.
Mechanism of actionRecent studies have found that the generating mechanism from phenylbutazone anti-inflammatory, analgesic and anti-rheumatic effect is not due to pituitary-adrenal excitement may be due to drugs that inhibit the generation of inflammatory tissue inflammation related active substances, such as synthesis of prostaglandins, white blood cells activities and transfer, release and activity of lysosomal enzymes; pain may also inhibit prostaglandin synthesis results.
Pharmacokinetic StudyOral absorption effect is quickly and completely, reached the peak plasma concentration after about 2 hours. Plasma protein binding rate is 98%. The apparent volume of distribution is 0.12L/kg, such as increasing the dose, volume of distribution has also increased, but the blood concentration does not increase. Therefore, when using repeatedly, the steady-state plasma concentration does not increase linearly. The half-life is 56 to 86 hours. It can cross the placenta into the milk. This product is metabolized by the liver, metabolites is hydroxy phenylbutazone and γ-hydroxy phenylbutazone, still active, The final metabolites are excreted in urine and a small amount of bile is excreted through the urine.
Attention and TabooThe side effects of phenylbutazone incidence rate is about 10%~20%, gastrointestinal irritation can cause nausea, vomiting, abdominal pain, constipation, overdose can cause peptic ulcer, blood in the stool. Damages also occur in other systems, such as rash, dizziness, hematuria, hepatitis, etc. Inhibit the bone marrow caused by neutropenia, or even aplastic anemia, such as the timely withdrawal is more recoverable and therefore should be ground check blood, no effect by 1 week, should not be reused. And double coumarin anticoagulants, sulfonamides, tolbutamide hypoglycemic drugs, increase the plasma concentration, toxicity increases. Sodium, chlorine retention effect, hypertension, edema, heart failure patients cannot use it and limit salt intake during the treatment. Patients with weak liver, osteoporosis, and kidney as well as drug allergy history are contraindicated or appropriate caution.
PreparationCyclization reaction of hydrogenated azobenzene and diethylmalonic acid diethyl: hydrazobenzene, butyl diethyl malonate, sodium sulfite and methanol are heated with severe reflux 1.5h, born in Bute salt, acidified with acetic acid to give Bute.
Acute toxicityoral-rat LD50: 245 mg/kg; Oral-Mouse LD50: 270 mg/kg
Irritation Data: Eye – rabbit, 100 mg, moderate
Flammability hazard propertiesthermal decomposition emitted poisonous nitrogen oxides fumes
Storage characteristicsTreasury ventilation low-temperature drying; and food raw materials stored separately
Extinguishing agentWater, carbon dioxide, dry powder, foam
Referenceshttps://en.wikipedia.org/wiki/Phenylbutazone
https://pubchem.ncbi.nlm.nih.gov/compound/phenylbutazone#section=Top
http://www.medicinenet.com/phenylbutazone/article.htm
Chemical PropertiesOff-Whtie Solid
UsesFor the treatment of backache and ankylosing spondylitis
UsesAn inhibitor of Cox.
UsesPhenylbutazone, a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of COX. Phenylbutazone-dependent inactivation of COX and prostacyclin synthase is markedly increased in the presence of 100 μM hydrogen peroxide with half-maximal effects at Phenylbutazone concentrations of 100 and 25 μM for COX and prostacyclin synthase, respectively.
UsesA non-steroidal anti-inflammatory compound. An inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase
Brand nameAzolid (Sanofi Aventis); Butazolidin (Novartis);Algesin;Algirreudin;Algoverine;Alka butazolidin;Alkabutazone;Alka-phenylbutazone;Alka-sterazolidin;Anarthral;Apophenylbutazone;Apo-phenylbutazone;Arteopan;Arthirikin;Artibrin;Artrisin;Artrodesmol extra;Bizolin 20;Bizolin 700;Butacal;Butacol;Butadilat;Butadin;Butadyne;Butafenil;Butagros;Butakvertin;Butaparin;Butaphen;Buta-phen;Butarex;Butartiril;Butatril;Butazolidin alka;Butazolidina;Butial;Butinol;Butiwas;Buto beta;Butoroid cream;Butrex;Carudol;Celestalgon;Celestazone;Colfezone;Corbuvit;Dartranol;Debutazon;Delta-butazolidin;Delta-demoplas;Delta-myogit;Delta-tomanol;Deltawaukobuzon;Dephimixn;Dexa tomanol;Dexa-attritin;Dexa-escopyrin;Dexamed;Dexatrzona;Dibuzon;Direstop;Ditrone;Doctofril;Dolosin dexa;Dolpirina;Ectobutazone;Ethibute;Exraheudon;Exrheudon;F 650;Fenibutina;Flebosil;Glycyl;Hepabuzon;Inflazone;Intrabuzone;Mammyl;Megazone;Mepha-butazone;Mepropyrin;Mi 540;Naupax;Neuro-demoplas;Neuzoline m;Novobutazone;Oluprin;Oppazoen;Osadrinim;Parazolidin;Parzolidon;Pasirheuman;Penetradol;Phenbuff;Phenbutazone;Phenylarthrite;Phenylbetazone;Phenylon plus;Phlebolan;Pirabutil;Pirarreumol-b;Pirarreumol-p;Prebutex;Precirhemin;Prednirheumin;Proxyfezone;Proydynam;Pyrbutal;Ranocor;Reopin;Reumilene;Rheopyrin;Rheosolon;Rheumanoln;Rheumaphen;Rheumycalm;Salzone;Servizolidin;Sigma-elmedal;Sintobutina;Stabilat;Tevocodyn;Tibutazone;Ticinil calcio;Ticinil calico;Trabit;Zolapelin;Zolidinium.
World Health Organization (WHO)Phenylbutazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1949 for the treatment of rheumatic disorders. Its use was subsequently associated with serious and sometimes fatal adverse reactions, notably cases of aplastic anaemia and agranulocytosis. Many national drug regulatory authorities consider that more recently introduced drugs offer a safer alternative for most, if not all, patients requiring anti-inflammatory agents. Phenylbutazone has thus been either withdrawn at the national level or retained with rigorously restricted indications for patients unresponsive to other therapy. These restrictions also apply, in general, to combination products containing phenylbutazone.
General DescriptionOdorless white or off-white crystalline powder. Tasteless at first, but slightly bitter aftertaste. pH (aqueous solution) 8.2.
Air & Water ReactionsPhenylbutazone is relatively stable at ambient temperatures. Aqueous decomposition of Phenylbutazone occurs by hydrolysis and oxidation. Insoluble in water.
Reactivity ProfilePhenylbutazone is incompatible with strong oxidizers, strong acids and strong bases. .
Fire HazardFlash point data for Phenylbutazone are not available; however, Phenylbutazone is probably combustible.
Safety ProfileSuspected human carcinogen producing leukemia. A human poison by parenteral route. An experimental poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Human systemic effects by ingestion and possibly other routes: fever, blood pressure increase, other unspecified vascular effects, damage to kidney tubules and glomeruli, decreased urine volume, blood in the urine, reduction in the number of whte blood cells, and agranulocytosis. Experimental teratogenic and reproductive effects. Human mutation data reported. An eye irritant. An antiinflammatory agent. When heated to decomposition it emits toxic fumes of NOx
Veterinary Drugs and TreatmentsOne manufacturer lists the following as the indications for phenylbutazone: “For the relief of inflammatory conditions associated with the musculoskeletal system in dogs and horses.” (Package Insert; Butazolidin?—Coopers). It has been used primarily for the treatment of lameness in horses and, occasionally, as an analgesic/ antiinflammatory, antipyretic in dogs, cattle, and swine.
Purification MethodsCrystallise the dione from EtOH. Its pK2 3 is 4.52 (in H2O), 4.89 (in 50% aqueous EtOH) and 5.25 (80% 2-methoxyethanol). It complexes with Hg2+, Cd2+ and Zn2+. It has UV with max at 239.5nm in MeOH+50% aqueous HClO4 and 264nm in aqueous 0.1N NaOH. [Beilstein 24 III/IV 1123.]
Phenylbutazone Preparation Products And Raw materials
Raw materialsSodium methanolate-->1-Butanol-->Sodium sulfite-->Sodium ethoxide-->Diethyl malonate-->Hydrazobenzene-->Diethyl butylmalonate-->Sodium butazolidine
Tag:Phenylbutazone(50-33-9) Related Product Information
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