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DL-Mevalonolactone

DL-Mevalonolactone Suppliers list
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one
CAS:674-26-0
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-64556
Company Name: Nanjing jinheyou Trading Co., Ltd.
Tel: 15705188088
Email: admin@jheyou.com
Products Intro: Product Name:DL-Mevalonolactone
CAS:674-26-0
Purity:95%min Package:1g;USD
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
Email: info@hnbon.com
Products Intro: CAS:674-26-0
Purity:0.99 Package:25KG;5KG;1KG;500G
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: 86-18523575427
Email: sales@conier.com
Products Intro: Product Name:dl-mevalonolactone
CAS:674-26-0
Purity:0.99 Package:1kg
Company Name: career henan chemical co
Tel: 0371-55982848 15093356674
Email: factory@coreychem.com
Products Intro: Product Name:DL-Mevalonolactone
CAS:674-26-0
Purity:>=98% Package:1KG;8USD

DL-Mevalonolactone manufacturers

  • DL-Mevalonolactone
  • $15.00-10.00 / KG
  • 2021-08-12
  • CAS:674-26-0
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • DL-Mevalonolactone
  • $8.00 / KG
  • 2020-03-06
  • CAS:674-26-0
  • Min. Order: 1g
  • Purity: ≥98%
  • Supply Ability: kg--tons
  • DL-Mevalonolactone
  • $6.60 / KG
  • 2019-12-27
  • CAS: 674-26-0
  • Min. Order: 1KG
  • Purity: 97%-99%
  • Supply Ability: 1kg-1000kg
DL-Mevalonolactone Basic information
Product Name:DL-Mevalonolactone
Synonyms:DL-MEVALONOLACTONE;β-Hydroxy-β-methyl-δ-valerolactone, (±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, (±)-Mevalolactone, (±)-Mevalonic acid lactone, (±)-Mevalonolactone;(4S)-4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one;(S)-3,5-Dihydroxy-3-methylpentanoic acid δ-lactone;(S)-4β-Hydroxy-4-methyltetrahydro-2H-pyran-2-one;(S)-Tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one;Beta-Hydro;(±)-Mevalonolactone,(±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, DL-Mevalolactone, DL-Mevalonic acid lactone
CAS:674-26-0
MF:C6H10O3
MW:130.14
EINECS:211-615-0
Product Categories:Heterocycles, Metabolites & Impurities;Heterocycles;Metabolites & Impurities
Mol File:674-26-0.mol
DL-Mevalonolactone Structure
DL-Mevalonolactone Chemical Properties
Melting point 28 °C(lit.)
Boiling point 145-150 °C5 mm Hg(lit.)
alpha -1.0~+1.0°(20℃/D)(c=5, C2H5OH)
density 1.1066 (rough estimate)
refractive index n20/D 1.473(lit.)
Fp >230 °F
storage temp. -20°C
pka13.57±0.20(Predicted)
Merck 14,6163
BRN 80960
Stability:Hygroscopic
InChIKeyJYVXNLLUYHCIIH-UHFFFAOYSA-N
CAS DataBase Reference674-26-0(CAS DataBase Reference)
NIST Chemistry ReferenceDl-mevalonic acid lactone(674-26-0)
Safety Information
WGK Germany 3
3-10
HS Code 29322090
MSDS Information
ProviderLanguage
SigmaAldrich English
DL-Mevalonolactone Usage And Synthesis
DescriptionDL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria. DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos. 10010344 | 10010345) in L6 myotubes. Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.
Chemical PropertiesPale Yellow Oil
UsesA metabolite from endophytes of the medicinal plant Erythrina crista-galli.
UsesHMG CoA substrate
Synthesis Reference(s)Journal of the American Chemical Society, 104, p. 5486, 1982 DOI: 10.1021/ja00384a040
Synthesis, p. 719, 1974 DOI: 10.1055/s-1974-23416
Purification MethodsPurify the lactone via the dibenzyl-ethylenediammonium salt (m 124-125o) [Hofmann et al. J Am Chem Soc 79 2316 1957], or by chromatography on paper or on a Dowex-1 (formate) column. [Bloch et al. J Biol Chem 234 2595 1959.] Store it as the N,N'-dibenzylethylenediamine (DBED) salt, or as the lactone in a sealed container at 0o. [Beilstein 18/1 V 19.]
DL-Mevalonolactone Preparation Products And Raw materials
Preparation Products3-METHYLPENTANE-1,3,5-TRIOL
Tag:DL-Mevalonolactone(674-26-0) Related Product Information
MEVALONOLACTONE-4,4,5,5,6,6,6-D7,DL-MEVALONOLACTONE-4,4,5,5,6,6,6-D7,DL-MEVALONOLACTONE-4,4,5,5,6,6,6-D7 DL-MEVALONOLACTONE-4,4,5,5-D4,MEVALONOLACTONE-4,4,5,5-D4,DL-MEVALONOLACTONE-4,4,5,5-D4 MEVALONOLACTONE-1,2-13C2, 99 ATOM % 13C, 98% CP,mevalonolactone-1,2-13c2 DL-MEVALONOLACTONE-5-13,DL-MEVALONOLACTONE-5-13 MEVALONOLACTONE-5-13C DL-MEVALONOLACTONE-D3 (METHYL-D3,DL-MEVALONOLACTONE-D3 (METHYL-D3 Mevalonolactone-d3,DL-MEVALONOLACTONE-D3,MEVALONOLACTONE-D3 (METHYL-D3),MEVALONOLACTONE-(METHYL-D3),DL-MEVALONOLACTONE-D3 R,S-Mevalonolactone DL-MEVALONOLACTONE-13C1,DL-MEVALONOLACTONE-13C1 TRIOXSALEN 1,3-Dihydroxyacetone 3,5-Dihydroxybenzoic acid Ethyl 2-(Chlorosulfonyl)acetate DL-Mevalonolactone DL-Malic acid CHLOROPHOSPHONAZO III Hyaluronic acid Triclosan