L-DIHYDROOROTIC ACID

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Company Name:	Hebei Mujin Biotechnology Co.,Ltd
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Products Intro:	Product Name:L-DIHYDROOROTIC ACID CAS:5988-19-2 Purity:99% Package:25KG

Company Name:	Hebei Chuanghai Biotechnology Co., Ltd
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Company Name:	Capot Chemical Co.,Ltd.
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Products Intro:	Product Name:L-Hydroorotic acid CAS:5988-19-2 Purity:98%(Min) Package:100g;1kg;5kg,10kg,25kg,50kg

L-DIHYDROOROTIC ACID manufacturers

L-DIHYDROOROTIC ACID Basic information

Product Name:	L-DIHYDROOROTIC ACID
Synonyms:	L-DIHYDROOROTIC ACID;(S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid;2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid;L-4,5-Dihydroorotic acid~(S)-(+)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid;(S)-(+)-HYDROOROTIC ACID;(4S)-2,6-dioxo-1,3-diazinane-4-carboxylic acid;L-4,5-dihydroorotic acid;(S)-4,5-dihydroorotate
CAS:	5988-19-2
MF:	C5H6N2O4
MW:	158.11
EINECS:	624-952-7
Product Categories:	Heterocycles;Miscellaneous Biochemicals;Amino Acid Derivatives;5988-19-2
Mol File:	5988-19-2.mol

L-DIHYDROOROTIC ACID Chemical Properties

Melting point	254-255 °C (dec.)(lit.)
Boiling point	283.16°C (rough estimate)
density	1.523
refractive index	1.5090 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Slightly), Water (Slightly, Heated, Sonicated)
pka	2.82±0.20(Predicted)
form	Powder
color	White to off-white
Water Solubility	Soluble in water (partly), and dimethyl formamide.
InChIKey	UFIVEPVSAGBUSI-REOHCLBHSA-N
CAS DataBase Reference	5988-19-2(CAS DataBase Reference)
NIST Chemistry Reference	Orotic acid, dihydro-, l-(5988-19-2)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

L-DIHYDROOROTIC ACID Usage And Synthesis

Chemical Properties	White to off-white crystalline powder
Uses	L-Dihydroorotic acid a metabolite.
Definition	ChEBI: (S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid.
Biochem/physiol Actions	L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.
IC 50	Microbial Metabolite; Human Endogenous Metabolite

L-DIHYDROOROTIC ACID Preparation Products And Raw materials

Raw materials	Orotic acid
Preparation Products	Disodium 5'-Inosinate-->Ribavirin-->CALCIUM5'-RIBONUCLEOTIDES-->Idoxuridine

Tag:L-DIHYDROOROTIC ACID(5988-19-2) Related Product Information

UDP SODIUM SALT URIDINE 5'-DIPHOSPHORIC ACID SODIUM SALT 2'-Deoxyuridine Cytidine-5'-diphosphate disodium salt Inosine CTP xsodium ATP disodium salt Uridine-5'-diphosphate disodium salt Orotic acid Sodium phosphate tribasic dodecahydrate Trisodium phosphate 1-METHYL-L-4,5-DIHYDROOROTIC ACID L-DIHYDROOROTIC ACID DL-Hydroorotic acid D-HYDROOROTIC ACID Sulbactum Sodium Cytidine 5′-(tetrahydrogen triphosphate), xsodium salt, hydrate 4,5-Dihydroorotic acid

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