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Aceclofenac

Aceclofenac Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
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Products Intro: Product Name:Aceclofenac
CAS:89796-99-6
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Guangzhou PI PI Biotech Inc
Tel: ; +8618371201331;+8618371201331
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Products Intro: Product Name:Aceclofenac
CAS:89796-99-6
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:[[[2-[(2,6-Dichlorophenyl)amino]phenyl]acetyl]oxy]acetic acid
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: CAS:89796-99-6
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
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Products Intro: Product Name:Aceclofenac
CAS:89796-99-6
Purity:USP BP EP Package:1KG;5USD
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:2-[[2[2[(2,6-Dichlorophenyl)Amino]Phenyl]Acetyl]Oxy]Acetic Acid
CAS:89796-99-6
Purity:98% Package:1g/5g/25g/100g

Aceclofenac manufacturers

  • Aceclofenac
  • $12.00 / g
  • 2021-11-27
  • CAS:89796-99-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 5ton/Month
  • Aceclofenac
  • $60.00 / KG
  • 2021-11-16
  • CAS:89796-99-6
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 100kg
  • Aceclofenac
  • $10.00 / KG
  • 2021-11-08
  • CAS:89796-99-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100MT/Month
Aceclofenac Basic information
Description Mechanism of Action Precautions
Product Name:Aceclofenac
Synonyms:ACECLOFENAC;ACECLOFENAC-D2;Airtal;Falcol;Gerbin;Glycolic Acid [o-(2,6-Dichloroanilino)phenyl]acetate Ester;PR-82/3;Preservex
CAS:89796-99-6
MF:C16H13Cl2NO4
MW:354.18
EINECS:641-844-5
Product Categories:Free Base API;API;Active Pharmaceutical Ingredients;Lipid signaling;Aromatics;AIRTAL;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:89796-99-6.mol
Aceclofenac Structure
Aceclofenac Chemical Properties
Melting point 149-153°C
Boiling point 486.0±45.0 °C(Predicted)
density 1.455±0.06 g/cm3(Predicted)
RTECS CY1577900
storage temp. 2-8°C
solubility Soluble in DMSO
form powder
pka2.60±0.10(Predicted)
color off-white to light tan
Water Solubility 32mg/L(32 ºC)
Merck 14,22
InChIKeyMNIPYSSQXLZQLJ-UHFFFAOYSA-N
CAS DataBase Reference89796-99-6(CAS DataBase Reference)
EPA Substance Registry SystemBenzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, carboxymethyl ester (89796-99-6)
Safety Information
Hazard Codes T,N
Risk Statements 25-36-50/53
Safety Statements 26-45-60-61
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
HazardClass 6.1
PackingGroup III
HS Code 29224999
MSDS Information
Aceclofenac Usage And Synthesis
DescriptionAceclofenac is a non-steroidal anti-inflammatory drug (NSAIDs) that is commonly prescribed for people with painful rheumatic conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
The drug should not be given to children, breastfeeding mothers, and people with porphyria. Pregnant women should not also be given aceclofenac as they risk developing patent ductus arteriosus in the neonate.
Mechanism of ActionAceclofenac acts by inhibiting the effect of natural substances known as cyclooxygenase (COX) enzymes. Notably, these enzymes are responsible for making other chemicals in the body, namely prostaglandins. The prostaglandins are normally produced at sites of damages or injury cause inflammation and pain. By blocking the influence of COX enzymes, production of prostaglandins is minimized, meaning that the swelling and pain is eased.
PrecautionsBefore taking aceclofenac, it is essential to tell the doctor if one has ever had an allergic reaction to any other NSAID, for instance, diclofenac, aspirin, indomethacin, and naproxen; whether one has allergic disorders such as asthma. It is important to alert the doctor if an individual has a heart condition or problem with circulation or blood vessels. Moreover, inform the physician if one has connective tissue disorder, for instance, lupus erythematosus. One should not take the drug if he/she has high blood pressure or has blood-clotting problems.
DescriptionAceclofenac is a nonsteroidal antiinflammatory agent with analgesic and antipyretic properties. It is reported to be useful in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with minor surgical procedures. Compared to ketoprofen in the treatment of rheumatoid arthritis, aceclofenac is substantially faster acting.
Chemical PropertiesWhite Crystalline Solid
OriginatorProdes (Prodesfarma) (Spain)
UsesLabeled Aceclofenac, intended for use as an internal standard for the quantification of Aceclofenac by GC- or LC-mass spectrometry.
DefinitionChEBI: A monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Manufacturing Process50 g of sodium 2-[(2,6-dichlorphenyl)amino]phenylacetate were dissolved in 300 ml of N,N-dimethylformamide under heating to 50°C, and 44.22 g of benzyl bromoacetate were added thereto. Under these condition stirring was continued for 9 hours. Upon completion of the reaction, the solvent was removed at reduced pressure, and the sodium salt were precipitated with addition of 400 ml of ether. The solution was then filtered and the ether phase was washed twice time with 100 ml of hexane. The resulting product was crystallized from the hexane/ether and then from acetone/chloroform (1:9) thus obtaining 44.1 g (61%) of benzyl 2-[(2,6- dichlorphenyl)amino]phenylacetoxyacetate in the form of white crystals having a melting point of 67-69°C.
45.28 g of benzyl 2-[(2,6-dichlorphenyl)amino]phenylacetoxyacetate were dissolved in 1500 ml of ethyl acetate, and the resulting solution was mixed with 7 g of Pd/C 10% and then hydrogen ted at atmospheric pressure for 14 hours. The solution was filtered, concentrated and crystallized; thereby obtaining 23.51 g (65%) of 2-[(2,6-dichlorphenyl)amino]phenylacetoxyacetic acid; melting point 149-150°C.
Brand nameAirtal; Gerbin
Therapeutic FunctionAnalgesic, Antiinflammatory
Aceclofenac Preparation Products And Raw materials
Raw materialsBenzyl 2-bromoacetate
Tag:Aceclofenac(89796-99-6) Related Product Information
Oxalic acid 2-NAPHTHOL-8-SULFONIC ACID POTASSIUM SALT ACECLOFENAC IMPURITY H,ACECLOFENAC IMPURITY H ACECLOFENAC IMP. I (EP): 1-(2,6-DICHLOROPHENYL)-1,3-DIHYDRO-2H-INDOL-2-ONE,ACECLOFENAC IMP. I (EP): 1-(2,6-DICHLOROPHENYL)-1,3-DIHYDRO-2H-INDOL-2-ONE ACECLOFENAC - REFERENCE SPECTRUM,ACECLOFENAC - REFERENCE SPECTRUM Articaine Aceclofenac,Anti-Inflammatory&Analgesics,Aceclofenac,Anti-Inflammatory&Analgesics ACECLOFENAC IMPURITY F,ACECLOFENAC IMPURITY F DICLOFENAC METHYL ESTER METHYL (2-AMINO-PHENYL)-ACETATE (2-AMINO-PHENYL)-ACETIC ACID ETHYL ESTER (2-AMINO-PHENYL)-ACETIC ACID ETHYL ESTER HCL (2-CHLORO-PHENYL)-PHENYL-AMINE 2-ANILINOPHENYLACETIC ACID PHENYLETHYL OXYACETALDEHYDE 2,6-DICHLORODIPHENYLAMINE GLYCOLIC-2,2-D2 ACID Sodium triacetoxyborohydride