- Acetyl tributyl citrate
-
- $100.00 / 1KG
-
2023-12-24
- CAS:77-90-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
|
| | Acetyl tributyl citrate Basic information |
| | Acetyl tributyl citrate Chemical Properties |
| | Acetyl tributyl citrate Usage And Synthesis |
| Chemical Properties | clear colorless liquid | | Chemical Properties | Acetyltributyl citrate is a clear, odorless, practically colorless, oily
liquid. | | Chemical Properties | Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents. | | Chemical Properties | Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has
a mild, fruity, nondescript flavor. | | Uses | plasticizer flavoring agent | | Uses | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. | | Uses | Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester. | | Definition | Aqueous-based pharmaceutical coat-
ings. | | Production Methods | Acetyltributyl citrate is prepared by the esterification of citric acid
with butanol followed by acylation with acetic anhydride. | | Preparation | From citric acid via the tributyl ester followed by acetylation. | | General Description | Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | | Pharmaceutical Applications | Acetyltributyl citrate is used to plasticize polymers in formulated
pharmaceutical coatings, including capsules, tablets, beads, and
granules for taste masking, immediate release, sustained-release
and enteric formulations. | | Safety Profile | When heated to decomposition it emits acrid smoke and irritating fumes.
ADD750 | | Safety | and films intended for direct food contact. It is also used in selfadhesive
thin films used for topical delivery systems. It is generally
regarded as a relatively nontoxic and nonirritating material.
However, ingestion of large quantities may be harmful.
LD50 (cat, oral): >50 mL/kg
LD50 (mouse, IP): >4 g/kg
LD50 (rat, oral): >31.5 g/kg | | Carcinogenicity | The chronic toxicity of ATBC
was evaluated in rats fed diets containing 200, 2000, or
20,000 ppm of ATBC for 2 years. There were no treatment-
related lesions in any organs examined. | | storage | Acetyltributyl citrate should be stored in a well-closed container in a
cool, dry location at temperatures not exceeding 38℃. When stored
in accordance with these conditions, acetyltributyl citrate is a stable
product. | | Incompatibilities | Acetyltributyl citrate is incompatible with strong alkalis and
oxidizing materials. | | Regulatory Status | Included in FDA Inactive Ingredients Database (oral capsules and
tablets). Included in nonparenteral medicines licensed in the UK.
Approved in the USA for direct food contact in food films. |
| | Acetyl tributyl citrate Preparation Products And Raw materials |
|