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BOC Sciences
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16314854226 |
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Product Name:CBFβ Inhibitor
CAS:493028-20-9
Purity:98% Package:1G;10G;100G Remarks:Core binding factors (CBFs) are heterodimeric transcription factors containing a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBFβ Inhibitor cellular studies indicate
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Changzhou Hopschain Chemical Co.,Ltd.
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Product Name:5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
CAS:493028-20-9
Purity:95+% Package:100mg;250mg;500mg;1g;2.5g;5g;10g
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:CBFβ Inhibitor
CAS:493028-20-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Basic information |
| Product Name: | 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE | | Synonyms: | TIMTEC-BB SBB011699;5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE;CBFβ Inhibitor;5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine;CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem;CBFβ Inhibitor;2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-;Runx1-CBFβ interaction inhibitor 1 | | CAS: | 493028-20-9 | | MF: | C12H14N2OS | | MW: | 234.32 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Chemical Properties |
| Boiling point | 421.6±40.0 °C(Predicted) | | density | 1.192±0.06 g/cm3(Predicted) | | storage temp. | +2C to +8C | | solubility | DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml | | form | Tan solid | | pka | 5.00±0.10(Predicted) |
| Hazard Codes | Xi | | HazardClass | IRRITANT |
| | 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Usage And Synthesis |
| Description | Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity. | | Uses | Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity. |
| | 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Preparation Products And Raw materials |
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