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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:ML367
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:ML367
CAS:381168-77-0
Purity:98% Package:5mg Remarks:V25685
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:ML367
CAS:381168-77-0
Package:100 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:ML367
CAS:381168-77-0
Purity:98% Package:$113.9/5mg;$395.9/25mg;$1270.9/100mg;$2403.9/250mg;Bulk package Remarks:98%
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
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Products Intro: Product Name:ML367
CAS:381168-77-0
Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Basic information
Product Name:N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
Synonyms:N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine;ML367;4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)-;ML-367,ML367,inhibit,ML 367,Inhibitor
CAS:381168-77-0
MF:C19H12F2N4
MW:334.32
EINECS:
Product Categories:
Mol File:381168-77-0.mol
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Structure
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Chemical Properties
storage temp. Store at -20°C
solubility DMSO: ≥ 125 mg/mL (373.89 mM)
Safety Information
MSDS Information
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Usage And Synthesis
Biological ActivityML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.
in vitro

ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.

Western Blot Analysis

< table class="zh_use_1">
Cell Line: HEK293T cells
Concentration: 0-40 μM in the presence or absence of 20 μM 5-Furd
Incubation Time: 16 hours
Result: Inhibited the increased ATAD5 protein levels induced by 5-Furd.
target
TargetValue
ATAD5
()
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Preparation Products And Raw materials
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