- CEPHALOTAXINE
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2026-09-11
- CAS:24316-19-6
- Min. Order: 20mg
- Purity: 98% HPLC
- Supply Ability: 100kg
- CEPHALOTAXINE
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-
2026-06-30
- CAS:24316-19-6
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
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| | CEPHALOTAXINE Basic information |
| Product Name: | CEPHALOTAXINE | | Synonyms: | (3aR)-2-Methoxy-(3arC4,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepin-1t-ol;[1S-(1a,3aS*,14b)]-1,5,6,8,9,14b-Hexahydro-2-methoxy-4H-cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1-ol;NSC 128487;NSC 245454;CEPHALOTAXINE FROM CEPHALOTAXUS &;Cephalotaxin;(1S,3aR,14bβ)-1,5,6,8,9,14b-Hexahydro-2-methoxy-4H-cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1α-ol;(4R)-7,8-(Methylenebisoxy)-3,4-(trimethylene)-4β,5β-[(3S)-2-methoxy-3-hydroxypropene-1,3-diyl]-1,2,4,5-tetrahydro-3H-3-benzoazepine | | CAS: | 24316-19-6 | | MF: | C18H21NO4 | | MW: | 315.36 | | EINECS: | | | Product Categories: | Heterocycles;Intermediates & Fine Chemicals;Alkaloids;Chiral Reagents;Pharmaceuticals | | Mol File: | 24316-19-6.mol |  |
| | CEPHALOTAXINE Chemical Properties |
| Melting point | 131-132 °C(Solv: benzene (71-43-2)) | | Boiling point | 495.2±45.0 °C(Predicted) | | density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | DMF: 10 mg/mL; DMSO: 12 mg/mL; Ethanol: 5 mg/mL | | form | powder to crystal | | pka | 13.30±0.40(Predicted) | | color | White to Orange to Green | | CAS DataBase Reference | 24316-19-6 |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | RIDADR | UN 1544 6.1/PG 3 | | WGK Germany | 3 | | HS Code | 2939.79.0000 | | HazardClass | 6.1(b) | | PackingGroup | III |
| | CEPHALOTAXINE Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | Antiviral and antitumor agent. | | Definition | ChEBI: A benzazepine alkaloid isolated from Cephalotaxus harringtonia. | | Synthesis | Sodium borohydride (27 mg, 0.70 mmol, 40 eq.) was added to a stirred solution of (-)-cephathione (S9) (5.5 mg, 18 μmol, 1.0 eq.) in methanol (0.65 mL) at -78 °C. The resulting white mixture was continued to be stirred at -78 °C for 10 minutes, followed by a slow warming to 25 °C and stirring at this temperature for 1 hour. Upon completion of the reaction, the mixture was diluted with water (30 mL) and extracted with dichloromethane (4 x 15 mL). The organic phases were combined, dried with sodium sulfate, gravity filtered, and the filtrate was concentrated by rotary evaporation to afford the target product (-)-1 (5.2 mg, 95% yield) as a light yellow film. Thin layer chromatography (TLC) showed an Rf value of 0.08 (unfolding agent: 10% methanol/dichloromethane). The structure of the product was confirmed by 1H NMR (500 MHz, CDCl3), IR and HRMS (ESI): 1H NMR δ 6.68 (s, 1H, ArH), 6.65 (s, 1H, ArH), 5.90 (s, 2H, OCH2O), 4.93 (s, 1H, vinyl H), 4.76 (d, 1H, J = 9Hz, CH(OH )), 3.73 (s, 3H, OCH3), 3.68 (d, 1H, J = 9 Hz, ArCHCH(OH)), 3.35 (m, 1H, CH2), 3.08 (m, 1H, CH2), 2.92 (dd, 1H, J = 12, 11, 7 Hz, CH2), 2.54-2.62 (m, 2H, CH2), 2.36 (ddd, 1H, J = 14, 7Hz, CH2), 2.00 (m, 1H, CH2), 1.60-1.90 (m, 4H, CH2); IR (pure film) 3411 (broad peaks, weak), 2926 (medium), 1651 (medium), 1503 (medium), 1486 (strong), 1222 (strong) cm-1; HRMS (ESI) m/z: C18H22NO4 ([M+H]+) calculated value 316.1549, measured value 316.1559. | | References | [1] Journal of the American Chemical Society, 2006, vol. 128, # 32, p. 10370 - 10371
[2] Chemistry - A European Journal, 2008, vol. 14, # 14, p. 4293 - 4306
[3] Patent: WO2009/148654, 2009, A2. Location in patent: Page/Page column 135
[4] Phytochemistry (Elsevier), 1973, vol. 12, p. 2987 - 2991 |
| | CEPHALOTAXINE Preparation Products And Raw materials |
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