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Chloramphenicol palmitate

Chloramphenicol palmitate Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: Product Name:Chloramphenicol palmitate
Purity:99% Package:25KG;5KG;1KG
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Products Intro: Product Name:chloramphenicol palmitate
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Tel: +86-0371-86658258
Products Intro: Product Name: Chloramphenicol palmitate
Purity:85.0-99.8% Package:1KG;1USD
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: 15319487004
Products Intro: Product Name:Chloramphenicol palmitate

Chloramphenicol palmitate manufacturers

  • Chloramphenicol palmitate
  • $15.00 / 1KG
  • 2021-08-12
  • CAS:530-43-8
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Chloramphenicol palmitate Basic information
Product Name:Chloramphenicol palmitate
Synonyms:CHLORAMPHENICOL ALPHA-PALMITATE;CHLORAMPHENICOL PALMITATE;alpha-esterwithd-threo-(-)-2,2-dichloro-n-(beta-hydroxy-alpha-palmiticaci;cap-p;cap-palmitate;chloramphenicolmonopalmitate;CHLORAMPHENICAL PALMITATE;CHLOROAMPHENICOL PALMITATE VETRANAL,250
Product Categories:CHLOROPAL;BacteriostaticAlphabetic;CHAntibiotics;Standards for SupelMIPTM SPE;Antibiotics;C;Chemical Structure;Chromatography;OthersAnalytical Standards;Principle
Mol File:530-43-8.mol
Chloramphenicol palmitate Structure
Chloramphenicol palmitate Chemical Properties
Melting point 90 C
alpha D26 +24.6° (c = 5 in ethanol)
Boiling point 691.6±55.0 °C(Predicted)
density 1.2354 (rough estimate)
refractive index 1.7350 (estimate)
storage temp. Store at RT.
form neat
Water Solubility 8.423ug/L(25 ºC)
Merck 14,2077
BRN 2826438
CAS DataBase Reference530-43-8(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 40-36/37/38-20/21/22
Safety Statements 36/37-36-26
WGK Germany 3
RTECS RT4735000
HS Code 29414000
MSDS Information
Chloramphenicol palmitate Usage And Synthesis
DescriptionChloramphenicol palmitate is an orally bioavailable ester prodrug form of the antibiotic chloramphenicol. It is hydrolyzed in the small intestine to release chloramphenicol. Formulations containing chloramphenicol palmitate were previously used in the treatment of severe bacterial infections.
Chemical Propertieswhite crystals
OriginatorChloromycetin,Parke Davis,US,1951
UsesChloramphenicol palmitate is prepared by acylation of chloramphenicol with palmitic acid. Although chloramphenicol palmitate is a more hydrophobic drug which should enhance bioavailability, the primary advantage of the ester is to mask the taste of chloramphenicol in oral formulations. Chloramphenicol palmitate is significantly less active than chloramphenicol but acts as a prodrug, being readily hydrolysed by acid and esterase in the gut to release chloramphenicol.
Usesantibacterial, antirickettsial
UsesChloramphenicol Palmitate is a Chloramphenicol (C325030) derivative, a broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial.
Manufacturing Process1,674 g of palmitoyl chloride is added to 1,870 g of D(-)-threo-1-pnitrophenyl-2-dichloroacetamidopropane-1,3-diol (chloramphenicol) in 2,700 cc of pyridine and the solution stirred for 1 hour. The mixture is poured into 16 liters of water and the solid collected. Recrystallization of the crude product from benzene yields the desired D(+)-threo-1-p-nitrophenyl- 1dichloroacetamido-3-palmitoyloxypropane-1-ol in pure form: MP 90°C.
Brand nameChloromycetin Palmitate (Parke- Davis).
Therapeutic FunctionAntibacterial; Antirickettsial
General DescriptionChloramphenicol palmitate is the palmitic acid ester ofchloramphenicol. It is a tasteless prodrug of chloramphenicolintended for pediatric use. The ester must hydrolyze invivo following oral absorption to provide the active form.Erratic serum levels were associated with early formulationsof the palmitate, but the manufacturer claims that thebioavailability of the current preparation is comparable tothat of chloramphenicol itself.
Safety ProfileModerately toxic by oral route. An experimental teratogen. Other experimental reproductive effects. An antibiotic. When heated to decomposition it emits very toxic fumes of NOx and Cl-. See also other chloramphenicol entries.
Purification MethodsThe palmitate crystallises from *benzene or xylene with m 105-106o and [] D –39.5o (c 2, Et2O), max 267.3nm. [Edgerton et al. J Am Chem Soc 77 27 1955, Beilstein 13 IV 2753.]
Chloramphenicol palmitate Preparation Products And Raw materials
Raw materialsThionyl chloride-->Benzene-->2-Picoline-->Palmitic acid-->Chloramphenicol-->Palmitoyl chloride
Tag:Chloramphenicol palmitate(530-43-8) Related Product Information
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