Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
Tel: |
15076683720 |
Email: |
klq@cw-bio.com |
Products Intro: |
Product Name:MRT-81 CAS:1263132-08-6 Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
|
Company Name: |
ShangHai Biochempartner Co.,Ltd
|
Tel: |
17754423994 17754423994 |
Email: |
2853530910@QQ.com |
Products Intro: |
Product Name:MRT-81 CAS:1263132-08-6 Purity:98% HPLC LCMS Package:100mg;500mg;1g
|
Company Name: |
DC Chemicals
|
Tel: |
021-58447131 13564518121 |
Email: |
sales@dcchemicals.com |
Products Intro: |
Product Name:MRT-81 CAS:1263132-08-6 Purity:98% HPLC Package:100mg,250mg,1g
|
|
| 3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Basic information |
Product Name: | 3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide | Synonyms: | MRT-81;3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide;Smo,Smoothened,human,C3H10T1/2 cells,inhibit,Shh-light2 cells,rodent,BODIPY-cyclopamine,MRT81,MRT-81,rat granule cell precursors,Inhibitor,MRT 81;[1,1'-Biphenyl]-4-carboxamide, N-[2-methyl-5-[[thioxo[(3,4,5-trimethoxybenzoyl)amino]methyl]amino]phenyl]-;N-(2-Methyl-5-(3-(3,4,5-trimethoxybenzoyl)thioureido)phenyl)-[1,1'-biphenyl]-4-carboxamide;N-(2-Methyl-5-(3-(3,4,5-trimethoxybenzoyl)thioureido)phenyl)-[1,1'-biphenyl]-4-carboxamide | CAS: | 1263132-08-6 | MF: | C31H29N3O5S | MW: | 555.64 | EINECS: | | Product Categories: | | Mol File: | 1263132-08-6.mol | |
| 3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Chemical Properties |
density | 1.289±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | pka | 8.09±0.70(Predicted) | form | Solid | color | White to light yellow |
| 3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Usage And Synthesis |
Biological Activity | MRT-81 is a potent antagonist of human and rodent smoothened Smo receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer[1].
MRT-81 inbihits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatasepositive osteoblasts induced by the Smo agonist SAG (0.1 μM), with an IC50 value of 64 nM[1].MRT-81 (1-1000 nM) is a potent antagonist of SAG (0.01 μM)-induced proliferation of rat granule cell precursors (GCPs) with an IC50 less than 10 nM[1].MRT-81 (0, 0.1, 1, 10, 30, 100, 300, 1000 nM; 2 h; 37 °C) blocks BODIPY-cyclopamine (5 nM) binding to hSmo in a dose-dependent manner with an IC50 of 63 nM in HEK-hSmo cells[1]. | References | [1]. Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012 Feb 23;55(4):1559-71. |
| 3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Preparation Products And Raw materials |
|