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Parthenolide

Parthenolide Suppliers list
Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +8613288715578
Email: sales@hbmojin.com
Products Intro: Product Name:Parthenolide
CAS:20554-84-1
Purity:99% Package:25KG
Company Name: Shaanxi Haibo Biotechnology Co., Ltd
Tel: +86-02963020060 +86-18629295024
Email: hibo06@xaltbio.com
Products Intro: Product Name:Parthenolide
CAS:20554-84-1
Purity:99% Package:25kg Remarks:White Powder
Company Name: Chongqing Zhihe Biopharmaceutical Co., Ltd.
Tel: +86-18580541567 +86-17782035140
Email: sales@zhswyy.com
Products Intro: Product Name:Parthenolide
CAS:20554-84-1
Purity:>=98% Package:1kg;|5kg;|25kg
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008657128800458; +8615858145714
Email: fandachem@gmail.com
Products Intro: Product Name:(-)-Parthenolide
CAS:20554-84-1
Purity:As coa Package:As request Remarks:20554-84-1
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:Parthenolide
CAS:20554-84-1
Purity:HPLC>=98% Package:20mg

Parthenolide manufacturers

  • Parthenolide
  • Parthenolide pictures
  • $0.00 / 1kg
  • 2024-03-29
  • CAS:20554-84-1
  • Min. Order: 0.10000000149011612kg
  • Purity: ≥98%
  • Supply Ability: 20tons
  • parthenolider
  •  parthenolider  pictures
  • $50.00 / 1g
  • 2024-03-29
  • CAS:20554-84-1
  • Min. Order: 2g
  • Purity: 99
  • Supply Ability: 10000 kilograms/month
Parthenolide Basic information
Product Name:Parthenolide
Synonyms:[1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one;(1aR,4E,7aS,10aS,10bS)-2,3,6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one;4,5α-Epoxy-6β-hydroxygermacra-1(10),11(13)-dien-12-oic acid γ-lactone;4,5alpha-epoxy-6beta-hydroxy-germacra-1(10),11(13)-dien-12-oic acid gamma-lactone;Germacra-1(10),11(13)-dien-12-oic acid, 4,5-alpha-epoxy-6-beta-hydroxy-, gamma-lactone;Parthenolide;Parthenolide ((-)-Parthenolide);PartheNAlide
CAS:20554-84-1
MF:C15H20O3
MW:248.32
EINECS:692-532-0
Product Categories:inhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Natural Product;Sesqui-Terpenoids;Isoprenoid/terpenoidNeurotransmitters;Anti-Proliferative AgentsNutrition Research;Antitumor Agents;Biochemicals Found in Plants;Cancer Research;Others;Serotonergics;Prostanoid receptor and related
Mol File:20554-84-1.mol
Parthenolide Structure
Parthenolide Chemical Properties
Melting point 115-116 °C (lit.)
alpha D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2)
Boiling point 394.1±42.0 °C(Predicted)
density 1.13±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml)
form White solid
color White
Merck 14,7048
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIInChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1
InChIKeyKTEXNACQROZXEV-PVLRGYAZSA-N
SMILESO1C(=O)C(=C)[C@]2([H])CCC(C)=CCC[C@@]3(C)O[C@]3([H])[C@@]12[H] |t:10|
LogP2.424 (est)
CAS DataBase Reference20554-84-1
Safety Information
Hazard Codes Xi,C,F
Risk Statements 11-34
Safety Statements 22-24/25-45-36/37/39-26-16
WGK Germany 3
RTECS LY4220000
HS Code 29322090
MSDS Information
ProviderLanguage
SigmaAldrich English
Parthenolide Usage And Synthesis
DescriptionParthenolide is an allergen in feverfew (Tanacetum parthenarium).
Chemical PropertiesWhite solid
UsesParthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.
UsesAntiinflammatory;MAP kinase inhibitor
UsesParthenolide is an anti-inflammatory agent used in the treatment of ischemic injury. Also acts as an anti-tumor and anti0leukemia agent targetting acute myeloid leukemia.
DefinitionChEBI: A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).
General DescriptionThis substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological ActivityThe active principle of feverfew (Chrysanthemum parthenium), widely used as a herbal remedy for arthritis and migraine and as a febrifuge. Parthenolide is antisecretory, anti-inflammatory, spasmolytic and inhibits the release of 5-HT from blood platelets. Also inhibits generation of leukotriene B 4 and thromboxane B 2 .
Contact allergensParthenolide is a sesquiterpene lactone found Asteraceae- Compositae such as feverfew (Tanacetum parthenium Schultz-Bip.) or congress grass (Parthenium hysterophorus L.).
Biochem/physiol ActionsParthenolide is a sesquiterpene lactone present abundantly in the leaves and flowers of Tanacetum parthenium. It exhibits anti-cancer properties for the treatment of invasive cancers. Parthenolide exhibits therapeutic effects against inflammation and migraine. It plays a role in signal transduction and activation of transcription (STAT)-inhibition-mediated transcriptional repression of pro-apoptotic genes.
References1) Kwok et al. (2001), The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase; Chem. Biol., 8 759 2) Hwang et al. (1996), Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sequiterpene lactones in macrophages correlates with the inhibition of MAP kinases; Biochem. Biophys. Res. Commun., 226 810 3) Barsby et al. (1992), Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta; J. Pharm. Pharmacol., 44 737 4) Sumner et al. (1992), Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components; Biochem. Pharmacol., 43 2313 5) Groenewegen et al. (1990), A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro; J. Pharm. Pharmacol., 42 553
Parthenolide Preparation Products And Raw materials
Tag:Parthenolide(20554-84-1) Related Product Information
D-(+)-Glucono-1,5-lactone Spironolactone Kauniolide Glycidyl methacrylate 2-BUTOXYETHYL ACRYLATE Glycidyl acrylate CITRONELLYL BUTYRATE 6-decenoic acid Allyl glycidyl ether Glycidyl butyrate METHYL TUBERATE 1,2-EPOXY-5-HEXENE (S)-(+)-Glycidyl butyrate 2-N-BUTOXYETHYL METHACRYLATE Tulipalin A Whiskey lactone FEVERFEW Parthenolide