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| | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Basic information |
| Product Name: | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide | | Synonyms: | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide;C-176;C-176 STING inhibitor;STING inhibitor 1;2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-;N-(4-iodophenyl)-5-nitro-2-furamide;STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA | | CAS: | 314054-00-7 | | MF: | C11H7IN2O4 | | MW: | 358.09 | | EINECS: | | | Product Categories: | | | Mol File: | 314054-00-7.mol |  |
| | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Chemical Properties |
| Boiling point | 361.2±37.0 °C(Predicted) | | density | 1.935±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | Soluble in DMSO (up to 25 mg/ml) | | pka | 11.14±0.70(Predicted) | | form | solid | | color | Brown or yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Usage And Synthesis |
| Description | C-176 (314054-00-7) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation?via?blockade of palmitoylation at Cys91. Treatment of Trex-/-?mice with C-176 resulted in a significant reduction in serum levels of Type I Interferons and amelioration of systemic inflammation. | | storage | Store at -20°C | | References | 1)Haag?et al.?(2018),?Targeting STING with covalent small-molecule inhibitors; Nature?559?269 |
| | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Preparation Products And Raw materials |
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