粘噻唑
| 中文名称 | 粘噻唑 |
|---|---|
| 中文同义词 | 粘噻唑;黏硫菌素 |
| 英文名称 | MYXOTHIAZOL |
| 英文同义词 | MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS;MYXOTHIAZOL;5-dimethoxy-4-methyl-;7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide;myxothiazol from myxobacterium*myxococcus fulvus;MYXOTHIAZOL, VIAL WITH 10 MG*;MYXOTHIAZOL FROM MYXOBACTERIUM 95%;myxothiazolfrommyxobacterium |
| CAS号 | 76706-55-3 |
| 分子式 | C25H33N3O3S2 |
| 分子量 | 487.68 |
| EINECS号 | |
| 相关类别 | Inhibits an EnzymeNitric Oxide and Cell Stress;Mitochondrial InhibitorsAntibiotics;Antibiotics;Antibiotics A to;Antibiotics G-MAntibiotics;AntifungalAntibiotics;Cell Stress;Chemical Structure Class;Mechanism of Action;Peptides;Spectrum of Activity |
| Mol文件 | 76706-55-3.mol |
| 结构式 |  |
粘噻唑 性质
| 沸点 | 679.6±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.158±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 氯仿：可溶9.80 - 10.20mg/mL，透明，无色至黄色 |
| 酸度系数(pKa) | 14.07±0.50(Predicted) |
Myxothiazol 是一种抗真菌抗生素，是线粒体电子传递链复合体 Ⅲ (complex III or bc1 complex) 抑制剂。Myxothiazol 在0.01~3 μg/ml 浓度范围内可抑制许多酵母菌和真菌的生长。
Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml.
Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity.
Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality.
| Animal Model: | C57Bl/J6 mice |
| Dosage: | 0.56 mg/kg |
| Administration: | I.p.; 24 hours intervals for at most 4 times |
| Result: | A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found. |
安全信息
| 危险品标志 | T+ |
|---|---|
| 危险类别码 | 28 |
| 安全说明 | 28-36/37-45 |
| 危险品运输编号 | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS号 | QH7580000 |
| F | 10 |
| 危险等级 | 6.1(b) |
| 包装类别 | III |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-112177 | 粘噻唑 Myxothiazol | 76706-55-3 | 1 mg | 4200元 |
| 2023/03/20 | HY-112177 | 粘噻唑 Myxothiazol | 76706-55-3 | 5 mg | 10500元 |