MYXOTHIAZOL

MYXOTHIAZOL Suppliers list
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:MYXOTHIAZOL
CAS:76706-55-3
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Products Intro: Product Name:Myxothiazol
CAS:76706-55-3
Purity:95% Remarks:Myxothiazol is an antibiotic produced by Myxococcus fulvus MXfl6. It has activity against filamentou
Company Name: Sigma-Aldrich  
Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Products Intro: Product Name:Myxothiazol
CAS:76706-55-3
Purity:>=98% (HPLC) Package:1mg, 5mg Remarks:T5580
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840 18892239720
Email: psaitong@jm-bio.com
Products Intro: Product Name:Myxothiazol
CAS:76706-55-3
Purity:98%,from Myxococcus fulvus Mx f85 Package:1mg;5mg
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774
Email: sales@glpbio.cn
Products Intro: Product Name:Myxothiazol
CAS:76706-55-3
Purity:>98% Package:1mg;10mg;50mg;100mg;
MYXOTHIAZOL Basic information
Product Name:MYXOTHIAZOL
Synonyms:MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS;MYXOTHIAZOL;5-dimethoxy-4-methyl-;7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide;myxothiazol from myxobacterium*myxococcus fulvus;MYXOTHIAZOL, VIAL WITH 10 MG*;MYXOTHIAZOL FROM MYXOBACTERIUM 95%;myxothiazolfrommyxobacterium
CAS:76706-55-3
MF:C25H33N3O3S2
MW:487.68
EINECS:
Product Categories:Inhibits an EnzymeNitric Oxide and Cell Stress;Mitochondrial InhibitorsAntibiotics;Antibiotics;Antibiotics A to;Antibiotics G-MAntibiotics;AntifungalAntibiotics;Cell Stress;Chemical Structure Class;Mechanism of Action;Peptides;Spectrum of Activity
Mol File:76706-55-3.mol
MYXOTHIAZOL Structure
MYXOTHIAZOL Chemical Properties
Boiling point 679.6±65.0 °C(Predicted)
density 1.158±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility chloroform: soluble9.80 - 10.20mg/mL, clear, colorless to yellow
form Solid
pka14.07±0.50(Predicted)
color White to off-white
Safety Information
Hazard Codes T+
Risk Statements 28
Safety Statements 28-36/37-45
RIDADR UN 3462 6.1/PG 1
WGK Germany 3
RTECS QH7580000
10
HazardClass 6.1(b)
PackingGroup III
MSDS Information
ProviderLanguage
SigmaAldrich English
MYXOTHIAZOL Usage And Synthesis
UsesMyxothiazol has been used in as a mitochondrial electron transport chain (mETC) inhibitor in P19 murine embryonal carcinoma pluripotent cell line and to treat HeLa cells for integrated stress response activation.
DefinitionChEBI: A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S
Biochem/physiol ActionsMyxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain. Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain. Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.
MYXOTHIAZOL Preparation Products And Raw materials
Tag:MYXOTHIAZOL(76706-55-3) Related Product Information
2-Isopropyl-4-methyl thiazole 3-METHYL-1,5-HEPTADIENE 1,5-HEXADIEN-3-OL 2-Ethyl-4-methyl thiazole 4-METHYL-1-PENTEN-3-OL 2,4-Dimethylthiazole TRANS-2-METHYL-4-HEXEN-3-OL 2-isopropylthiazole 2-ETHYLTHIAZOLE 1,5-HEPTADIEN-4-OL 4-METHYL-1,5-HEPTADIENE MYXOTHIAZOL