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(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one

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Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:(2R,3R)-3-(2-(tert-butyldimethylsilyloxy)ethyl)-4-oxoazetidin-2-yl acetate
CAS:76855-69-1
Purity:98% (Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: Product Name:(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
CAS:76855-69-1
Purity:99% Package:25KG;5KG;1KG
Company Name: career henan chemical co
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Products Intro: Product Name: (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
CAS: 76855-69-1
Purity:99% Package:1kg;7USD
Company Name: Xiamen AmoyChem Co., Ltd
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Products Intro: Product Name:(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
CAS:76855-69-1
Company Name: CONIER CHEM AND PHARMA LIMITED
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Products Intro: Product Name:(3s,4r)-4-acetoxy-3-((r)-1-(tert-butyldimethylsilyloxy)ethyl)azetidin-2-one
CAS:76855-69-1
Purity:0.99 Package:1kg

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one manufacturers
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Basic information
Product Name:(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
Synonyms:(3s,4r)-4-acetoxy-3-[(r)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one;(3R,4R)-(+)-4-ACETOXY-3-[(R)-(T-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE;(3R,4R)-4-ACETOXY-3-[(R)-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE;(3R,4R)-4-(ACETYLOXY)-3-[(1R)-1-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]ETHYL]-2-AZETIDINONE;[3R(1'R,4R)]-(+)-4-ACETOXY-3-[1-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE;(2R,3R)-3-[(R)-1-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-4-OXOAZETIDIN-2-YLACETATE;4-AOSA;(3R,4R)-4-acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone
CAS:76855-69-1
MF:C13H25NO4Si
MW:287.43
EINECS:408-050-9
Product Categories:Aliphatics;Intermediates & Fine Chemicals;Amides (Chiral);Azetidines;Chiral Building Blocks;Pharmaceuticals;Monoalkoxysilanes;Si (Classes of Silicon Compounds);Simple 4-Membered Ring Compounds;Si-O Compounds;Synthetic Organic Chemistry;Chiral Building Blocks;Lactams;Organic Building Blocks;(intermediate of imipenem);Chiral Compound
Mol File:76855-69-1.mol
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Structure
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Chemical Properties
Melting point 107-109 °C(lit.)
alpha 51 º (c=1, chloroform)
Boiling point 358.3±27.0 °C(Predicted)
density 1.03±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility almost transparency in Methanol
form powder to crystal
pka12.86±0.60(Predicted)
color White to Almost white
Optical Rotation[α]20/D +51°, c = 1 in chloroform
InChIInChI=1S/C13H25NO4Si/c1-8(18-19(6,7)13(3,4)5)10-11(16)14-12(10)17-9(2)15/h8,10,12H,1-7H3,(H,14,16)/t8-,10+,12-/m1/s1
InChIKeyGWHDKFODLYVMQG-UBHAPETDSA-N
SMILESN1[C@H](OC(C)=O)[C@@H]([C@H](O[Si](C(C)(C)C)(C)C)C)C1=O
CAS DataBase Reference76855-69-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,N
Risk Statements 36-43-51/53
Safety Statements 24-26-37-61
RIDADR UN 3077 9/PG 3
WGK Germany 2
HazardClass 9
PackingGroup III
HS Code 29337900
Storage Class11 - Combustible Solids
Hazard ClassificationsAquatic Chronic 2
Eye Irrit. 2
Skin Sens. 1
MSDS Information
ProviderLanguage
SigmaAldrich English
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Usage And Synthesis
Chemical Propertieswhite to light yellow crystal powde
Uses(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one is an acetoxyazetidinone derivative used as an intermediate in the preparation of carbapenem antibiotics.
Purification MethodsPurify it by chromatography on silica gel (3 x 14cm) for 50g of ester using 20% EtOAc in n-hexane. The eluate is evaporated, and the residue is recrystallised from hexane (white fluffy crystals). [Leanza et al. Tetrahedron 39 2505 1983.]
Tag:(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one(76855-69-1) Related Product Information
Laurocapram Dimethyldimethoxysilane Ethylbenzene Benzyloxyacetyl chloride N-Methyl-2-pyrrolidone Ethyl formate Ethyl propionate Ethyl acrylate Ethylparaben 2-Butanone oxime 2-Azetidinone Diltiazem hydrochloride 4-Acetoxystyrene Ethyl acetate Diethoxydimethylsilane Sodium triacetoxyborohydride Ethanol T-BUTYLDIMETHYLSILANE