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Tocopheryl acetate

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CAS:7695-91-2
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Tocopheryl acetate manufacturers

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  • 2026-04-17
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Tocopheryl acetate Basic information
Product Name:Tocopheryl acetate
Synonyms:[2r-[2r*(4r*,8r*)]]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2h-1-benzopyran-6-ol acetate;Tocopherolacetat-alpha (high mass adjustment=50%);Tocopherolcetat-alpha (high mass adjustment=100%);2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanoacetate;2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate;2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate;O-ACETYL-ALPHA-TOCOPHEROL;RONACARE(R) ALL-RAC-ALPHA-TOCOPHERYL ACETATE
CAS:7695-91-2
MF:C31H52O3
MW:472.74
EINECS:231-710-0
Product Categories:food additives;Vitamin series;Organics;Antioxidant;Biochemistry;Vitamins;Vitamins and derivatives;7695-91-2
Mol File:7695-91-2.mol
Tocopheryl acetate Structure
Tocopheryl acetate Chemical Properties
Melting point -28°C
Boiling point 224 °C0.3 mm Hg(lit.)
density 0.96 g/mL at 20 °C (lit.)
vapor density 16.3 (vs air)
refractive index n20/D 1.497
Fp >230 °F
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in acetone, in anhydrous ethanol and in fatty oils.
form Viscous Liquid
Specific Gravity0.962 (20/4℃)
color Clear yellow viscous liquid
OdorOdorless
biological sourcesynthetic (organic)
Water Solubility Immiscible with water.
Sensitive Air & Light Sensitive
Merck 14,9495
BRN 97512
Major Applicationpharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products
Cosmetics Ingredients FunctionsSKIN CONDITIONING
ANTIOXIDANT
InChI1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1
InChIKeyZAKOWWREFLAJOT-CEFNRUSXSA-N
SMILESCC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1
LogP12.260 (est)
CAS DataBase Reference7695-91-2(CAS DataBase Reference)
NIST Chemistry Reference(+)-«ALPHA»-tocopherol acetate(7695-91-2)
EPA Substance Registry System2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate (7695-91-2)
Safety Information
Safety Statements 24/25
WGK Germany 1
RTECS GA8747000
8-10-23
Autoignition Temperature303°C
TSCA TSCA listed
HS Code 29362800
Storage Class10 - Combustible liquids
Tocopheryl acetate Usage And Synthesis
Chemical PropertiesLight yellow to yellow clear liquid
UsesAll-rac-alpha-tocopheryl acetate for peak identification may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.
UsesVitamin E (α-tocopherol) occurs naturally in most vegetable oils. The highest concentrations are found in com, soybean oils, sunflower seed, wheat germ, rapeseed, alfalfa, and lettuce. It is claimed to have age-retardant properties. May produce erythemamultiforme-like eruptions. It is used in a number of cosmetic products; creams are used for scars, striae, and bums; in pharmaeeutical ereams and deodorants; as an antioxidant in foods.
Usesvitamin E acetate (tocopherol acetate) is an anti-oxidant with skinmoisturizing activity. given its free-radical scavenging properties, it is useful in uV protective products. Vitamin e acetate is commonly used to replace vitamin e because it is more stable and is converted to vitamin e by the body.
Usesanti-Altzheimer therapeutic
DefinitionChEBI: DL-alpha-Tocopherol acetate is a tocol.
General DescriptionDL-α-Tocopherol acetate is a stable ester form of vitamin E, widely used in the formulation of cosmetics for the prevention or correction of skin damage.
HazardA reproductive hazard.
Flammability and ExplosibilityNon flammable
Contact allergensTocopherol and tocopheryl acetate are used mainly as antioxidants. Tocopheryl acetate, an ester of tocopherol (vitamin E), can induce allergic contact dermatitis.
Biochem/physiol ActionsTocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by Homosapiens. DL-α-Tocopherol acetate can inhibit oxidation of linoleate.
Purification MethodsIt is a viscous liquid which is purified by distillation under high vacuum under N2 or Ar and stored in sealed ampoules in the dark. It is considerably more stable to light and air than the parent unacetylated vitamin. It is insoluble in H2O but freely soluble in organic solvents. All eight stereoisomers have been synthesised. The commercially pure d-tocopheryl acetate (2R,4'R,8'R) has b 180-200o/0.7mm and [] D 20 +3.9o (c 5, EtOH); see above. [Cohen et al. Helv Chim Acta 64 1158 1981, Beilstein 17/4 V 169.]
Tag:Tocopheryl acetate(7695-91-2) Related Product Information
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