| | Acetoacetanilide Basic information |
| | Acetoacetanilide Chemical Properties |
| Melting point | 83-88 °C (lit.) | | Boiling point | 129°C 24mm | | density | 1.26 | | vapor density | 6.1 (vs air) | | vapor pressure | 0-0.013Pa at 20-50℃ | | refractive index | 1.5168 (estimate) | | Fp | 325 °F | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 12.21±0.46(Predicted) | | form | Crystalline Powder | | color | White | | Water Solubility | 5 g/L (20 ºC) | | Merck | 14,58 | | BRN | 473419 | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. | | LogP | 0.93 at 23℃ | | CAS DataBase Reference | 102-01-2(CAS DataBase Reference) | | NIST Chemistry Reference | Butanamide, 3-oxo-N-phenyl-(102-01-2) | | EPA Substance Registry System | Acetoacetanilide (102-01-2) |
| Hazard Codes | Xn | | Risk Statements | 21/22 | | Safety Statements | 36 | | RTECS | AK4200000 | | Autoignition Temperature | 843 °F | | HS Code | 2921419000 | | Hazardous Substances Data | 102-01-2(Hazardous Substances Data) | | Toxicity | LD50 orl-rat: 5400 mg/kg LONZA# 08FEB79 |
| | Acetoacetanilide Usage And Synthesis |
| Chemical Properties | White to off-white powder | | Uses | Acetoacetanilide is used as intermediate for the manufacture of organic pigments and dyestuffs. | | Uses | Acetoacetanilide may be used to synthesize:
- azo pigments
- acetoacetanilido-4-aminoantipyrine (Schiff base)
- 6-aryl-2-methyl-4-oxo-N,N′-diphenyl-2-cyclohexene-1,3-dicarboxamides
- photoluminescent lanthanide complexes
| | Uses | Acetoacetanilide (AAA) flakes is used as an intermediate for the manufacture of organic pigments and dyestuffs. For further information consult the Product information sheet. Product Data Sheet | | Synthesis Reference(s) | The Journal of Organic Chemistry, 56, p. 1713, 1991 DOI: 10.1021/jo00005a013 | | General Description | White crystalline solid. | | Air & Water Reactions | Water insoluble. | | Reactivity Profile | Organic amides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4. | | Health Hazard | ACUTE/CHRONIC HAZARDS: Acetoacetanilide is a weak allergen. When heated to decomposition it emits toxic fumes. | | Fire Hazard | Acetoacetanilide is combustible. | | Safety Profile | Poison by intraperitoneal route. Moderately toxic by ingestion. A weak allergen. See also ACETANILIDE. Combustible when exposed to heat or flame. See ANILINE and CYANIDE for disaster hazard. When heated to decomposition it emits toxic NOx, fumes. To fight fire, use alcohol foam, water mist, CO2, dry chemical. | | Purification Methods | Crystallise the anilide from H2O, aqueous EtOH or pet ether (b 60-80o). [Williams & Krynitsky Org Synth Coll Vol III 10 1955.] |
| | Acetoacetanilide Preparation Products And Raw materials |
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