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Wnt Antagonist I, IWR-1-endo - Calbiochem

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Products Intro: Product Name:Wnt Antagonist I, IWR-1-endo - Calbiochem
Wnt Antagonist I, IWR-1-endo - Calbiochem Basic information
Product Name:Wnt Antagonist I, IWR-1-endo - Calbiochem
Synonyms:Wnt Antagonist I, IWR-1-endo - Calbiochem
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Wnt Antagonist I, IWR-1-endo - Calbiochem Structure
Wnt Antagonist I, IWR-1-endo - Calbiochem Chemical Properties
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Wnt Antagonist I, IWR-1-endo - Calbiochem Usage And Synthesis
General DescriptionA cell-permeable p-imidobenzamidoquinoline, endo-diastereomer that is shown to inhibit the activity of TNKS1/PARP5a and TNKS2/PARP5b in in vitro auto-PARsylation assays (IC50 = 131 and 56 nM, respectively) and effectively suppress Wnt-stimulated transcription activity in L-Wnt-STF-based reporter assays (IC50 = 180 nM), while exhibiting little activity against PARP1 or PARP2 (IC50 >18.75 μM). Although both IWR-1-endo and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1-endo exerts its effect via interaction with Axin, while XAV939 binds TNKS directly.
Wnt Antagonist I, IWR-1-endo - Calbiochem Preparation Products And Raw materials
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