Clemizole hydrochloride

Clemizole hydrochloride Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: Product Name:Clemizole.HCl
CAS:1163-36-6
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Clemizole hydrochloride
CAS:1163-36-6
Purity:98% Package:1KG;1USD
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Email: linda@hubeijusheng.com
Products Intro: Product Name:1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole,hydrochloride
CAS:1163-36-6
Purity:0.99 Package:5KG;1KG
Company Name: BOC Sciences
Tel: 1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Clemizole hydrochloride
CAS:1163-36-6
Purity:95% Package:$198/100mg Remarks:The hydrochloride salt form of clemizole, which is a histamine H1 antagonist with antitumor activity. It also has hepatitis C antiviral effect through restraining NS4B function and could also be used
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: 86-18523575427
Email: sales@conier.com
Products Intro: Product Name:clemizole hydrochloride
CAS:1163-36-6
Purity:0.99 Package:1kg

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Clemizole hydrochloride Basic information
Product Name:Clemizole hydrochloride
Synonyms:1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride;1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole,hydrochloride;CS-1763;allercur;allercurehydrochloride;p48;1-P-CHLOROBENZYL-2-[1-PYRROLIDINYL]-METHYLBENZIMIDAZOLE HYDROCHLORIDE;1-[(4-Chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzoimidazole hydrochloride
CAS:1163-36-6
MF:C19H21Cl2N3
MW:362.3
EINECS:214-605-4
Product Categories:Inhibitors
Mol File:1163-36-6.mol
Clemizole hydrochloride Structure
Clemizole hydrochloride Chemical Properties
Melting point 239-241°
storage temp. 2-8°C
solubility H2O: soluble2mg/mL, clear (warmed)
form powder
color white to beige
Merck 14,2346
InChIKeyDNFMJYXRIMLMBZ-UHFFFAOYSA-N
CAS DataBase Reference1163-36-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 36
WGK Germany 3
RTECS DD6730000
MSDS Information
ProviderLanguage
SigmaAldrich English
Clemizole hydrochloride Usage And Synthesis
OriginatorAllercur,Roerig,US,1960
UsesClemizole is an antihistamine that antagonizes the histamine 1 receptor at high nanomolar concentrations. It less potently blocks transient receptor potential canonical channel 5 (TRPC5; IC50 = 1.0-1.3 μM), with at least 6-fold selectivity for TRPC5 over other TRP channels. Clemizole also has hepatitis C antiviral action through inhibition of NS4B function, showing synergy with boceprevir , and it inhibits seizures in a zebrafish model of Dravet Syndrome.
Manufacturing ProcessFrom 13.1 g of N-p-chlorobenzyl-2-nitroaniline (MP 110°C, obtained in the form of orange-red needles, from o-nitrochlorobenzene and pchlorobenzylamine by reaction for 3 hours at 150°C) by reduction with Raneynickel and hydrogen, in which reaction the substance may be suspended in methanol or dissolved in methanol-ethyl acetate at normal pressure and at about 40°C with combination of the theoretical quantity of hydrogen, 12.2 g are obtained of o-amino-N-p-chlorobenzylaniline, which after recrystallization from aqueous methanol has a MP of 90°C.
8 g of o-amino-N-p-chlorobenzylaniline and 2.8 g of pyridine are dissolved in dry ether and reacted with an ethereal solution of 3.9 g of chloracetyl chloride with cooling in a mixture of ice and common salt. 8 g of N-p-chlorobenzyl-N'- chloracetyl-o-phenylene diamine are obtained which can be worked up in the form of the crude product and, in the slightly colored form, has a MP of 130°C.
7.6 g of this compound are boiled with 3.9 g of pyrrolidine in 70 cc of toluene for some hours under reflux. After extraction by shaking with water and treatment with hydrochloric acid the hydrochloride is produced of N-pchlorobenzyl-N'-pyrrolidylacetyl-o-phenylene diamine together with some 1-pchlorobenzyl-2-N-pyrrolidylmethyl-benzimidazole. The former, after recrystallization from butanol, melts with foaming at 205°C, the latter, after recrystallization from butanol melts at 239°C to 241°C, and is in the form of white microscopic rods. Boiling in nitrobenzene converts the former compound into the latter.
Therapeutic FunctionAntihistaminic
Clemizole hydrochloride Preparation Products And Raw materials
Raw materials2-Nitrochlorobenzene-->2-Chlorobenzylamine-->Chloroacetyl chloride-->Pyrrolidine-->Sodium chloride
Tag:Clemizole hydrochloride(1163-36-6) Related Product Information
N-Ethylbenzimidazole Clemizole hydrochloride 1-(1H-IMIDAZOL-2-YL)-N,N-DIMETHYLMETHANAMINE C-(1-BENZYL-1H-IMIDAZOL-2-YL)-METHYLAMINE 2HCL N-METHYL-N-[(1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYL]AMINE N-Ethyl-2-methylbenzimidazole (1H-BENZOIMIDAZOL-2-YLMETHYL)-METHYL-AMINE 2-(AMINOMETHYL)-1-METHYLIMIDAZOLE 1-Benzylimidazole 1-METHYLBENZIMIDAZOLE 1-Benzyl-2-methyl-1H-imidazole 1-BENZYL-1H-BENZOIMIDAZOL-2-YL-METHYLAMINE DIHYDROCHLORIDE TIMTEC-BB SBB000240 Clemizole 2-AMINOMETHYLIMIDAZOLE HYDROCHLORIDE METHYL-(1-METHYL-1H-IMIDAZOL-2-YLMETHYL)-AMINE (1H-BENZO[D]IMIDAZOL-2-YL)METHANAMINE 1-(4-CHLOROBENZYL)-2-METHYLBENZIMIDAZOLE HCL