| Company Name: |
ChemCell Biomedicine Co.,Ltd.
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| Tel: |
020-13556033878 2965585218 13556033878 |
| Email: |
chemcell@hotmail.com |
| Products Intro: |
Product Name:BAY-707
CAS:2109805-96-9
Purity:98% Package:5mg;10mg;50mg;100mg,1g;5g;10g;50g;100g
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| | BAY707) Basic information |
| Product Name: | BAY707) | | Synonyms: | BAY-707
(BAY 707;BAY707);1H-Pyrrolo[2,3-b]pyridine-2-carboxamide, N-ethyl-4-[(3S)-3-methyl-4-morpholinyl]-;BAY-707 free base | | CAS: | 2109805-96-9 | | MF: | C15H20N4O2 | | MW: | 288.34 | | EINECS: | | | Product Categories: | | | Mol File: | 2109805-96-9.mol |  |
| | BAY707) Chemical Properties |
| density | 1.225±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:28.83(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:2.88(Max Conc. mg/mL);10.0(Max Conc. mM) | | pka | 14.36±0.40(Predicted) |
| | BAY707) Usage And Synthesis |
| Biological Activity | BAY-707 is a substrate-competitive, highly selective inhibitor of MTH1(NUDT1) with IC50 of 2.3 nM. It has a favorable pharmacokinetic profile compared to other MTH1 compounds and is well tolerated in mice, but the experiments clearly lack in vitro or in vivo anticancer efficacy. | | in vivo | Bay-077 (orally adminstation; 50-250 mg/kg; 2 weeks) exhibits superior biochemical potency, cellular target engagement, and a pharmacokinetic profile to other MTH1 tool compounds, But Bay-077 exerts no anticancer efficacy either in mono- or in combination therapies in CT26 and NCI-H460 mice model. | | target | IC50: 2.3 nM (MTH1/NUDT1) | | storage | Store at -20°C |
| | BAY707) Preparation Products And Raw materials |
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