| Company Name: |
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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| Tel: |
400-6206333 13167063860 |
| Email: |
anhua.mao@aladdin-e.com |
| Products Intro: |
Product Name:KHS101 hydrochloride
CAS:1784282-12-7
Purity:99% Package:25mg/RMB 2457.90;5mg/RMB 822.90;10mg/RMB 1209.90
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| | KHS101 hydrochloride Basic information |
| Product Name: | KHS101 hydrochloride | | Synonyms: | KHS101 hydrochloride;KHS 101,inhibit,Fibroblast growth factor receptor,Inhibitor,FGFR,KHS101,KHS-101 hydrochloride,KHS101 hydrochloride,KHS-101;KHS101 hydrochloride, 10 mM in DMSO | | CAS: | 1784282-12-7 | | MF: | C18H22ClN5S | | MW: | 375.92 | | EINECS: | | | Product Categories: | | | Mol File: | 1784282-12-7.mol |  |
| | KHS101 hydrochloride Chemical Properties |
| solubility | Soluble to 50 mM in DMSO and to 50 mM in ethanol | | form | Solid | | color | White to off-white |
| | KHS101 hydrochloride Usage And Synthesis |
| Uses | KHS 101 Hydrochloride is a useful intermediate. | | in vivo | Tumor cell proliferation is markedly reduced in KHS101-treated tumors (about twofold). KHS101-treated tumors show signs of elevated cell death (reduced cellularity/increased pyknosis) compared with tumors treated with vehicle control. KHS101 treatment markedly reduces both frontal-to-caudal tumor expansion and corpus callosum invasion of vimentin-positive GBM1 cells. It is also found that the survival of animals carrying GBMX1 tumors (established 2 or 6 weeks before treatment) is markedly increased by the KHS101 treatment regimen for 10 weeks. None of the mice have to be removed from the study because of adverse side effects of the treatment. An additional experiment using a continuous KHS101 treatment regimen until the experimental endpoints also shows a marked increase in the survival of GBMX1-bearing animals. Histological endpoint analysis of KHS101- and vehicle-treated animals confirms a significantly decreased tumor size in KHS101-treated mice[2]. | | storage | Desiccate at RT |
| | KHS101 hydrochloride Preparation Products And Raw materials |
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