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Cetylpyridinium chloride

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Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
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Purity:98% Package:g-Kg
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CAS:123-03-5
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CAS:123-03-5
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Products Intro: Product Name:Cetylpyridinium chloride
CAS:123-03-5
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Products Intro: Product Name:Cetylpyridinium chloride monohydrate
CAS:123-03-5
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Cetylpyridinium chloride Basic information
Product Name:Cetylpyridinium chloride
Synonyms:1-palmitylpyridiniumchloride;acetoquatcpc;aktivex;ammonyxcpc;biosept;ceeprinchloride;ceepryn;ceeprynchloride
CAS:123-03-5
MF:C21H38ClN
MW:339.99
EINECS:204-593-9
Product Categories:Inhibitors;Drugs & Medication
Mol File:123-03-5.mol
Cetylpyridinium chloride Structure
Cetylpyridinium chloride Chemical Properties
Melting point 77°C
Boiling point 496.25°C (rough estimate)
density 0.9362 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility Freely soluble in water; very soluble in chloroform; very slightly soluble in ether; insoluble in acetone, acetic acid, and ethanol.
form White Crystalline Powder
Stability:Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference123-03-5(CAS DataBase Reference)
EPA Substance Registry SystemCetylpyridinium chloride (123-03-5)
Safety Information
RIDADR 2811
HazardClass 6.1(b)
PackingGroup III
Hazardous Substances Data123-03-5(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Cetylpyridinium chloride English
Cetylpyridinium chloride Usage And Synthesis
Chemical PropertiesCetylpyridinium chloride (CPC) is a white powder or crystals with a characteristic odor. It is slightly soapy to the touch.
Cetylpyridinium chloride
Cetylpyridinium chloride is a quaternary ammonium compound and is the active chemical in some human mouthwashes on the market. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat. The antimicrobial activity is due to an interaction of basic cetylpyridinium ions with acidic molecules on bacteria, which subsequently inhibits bacterial metabolism by forming weak ionic compounds that interfere with bacterial respiration.
UsesAntibacterial in cough lozenges and syrups; emulsifier.
Usesquaternary ammonium compound used as a preservative in cosmetics and pharmaceuticals; topical anti-infective and disinfectant; used on the surface of latex gloves .
Production MethodsCetylpyridinium chloride is prepared from cetyl chloride by treatment with pyridine.
DefinitionChEBI: A pyridinium salt that has N-hexadecylpyridinium as the cation and chloride as the anion. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat.
Brand nameCeepryn (Marion Merrell Dow); Cepacol (Marion Merrell Dow).
Pharmaceutical ApplicationsCetylpyridinium chloride is a quaternary ammonium cationic surfactant, used in pharmaceutical and cosmetic formulations as an antimicrobial preservative. It is used therapeutically as an antiseptic agent; used alone or in combination with other drugs for oral and throat care; used in nonparenteral formulations licensed in the UK; and used in oral and inhalation preparations at concentrations of 0.02–1.5 mg.
Mouthwashes containing cetylpyridinium chloride have been shown to inhibit plaque formation,(1–3) although efficacy is variable owing to limited published data.
Clinical Use1-Hexadecylpyridinium chloride is a white powder that isvery soluble in water and alcohol. In this compound, thequaternary nitrogen atom is a member of an aromatic pyridinering.
The cetyl derivative is the most active of a series ofalkylpyridinium compounds. It is used as a general antisepticin concentrations of 1:100 to 1:1,000 for intact skin,1:1,000 for minor lacerations, and 1:2,000 to 1:10,000 forthe irrigation of mucous membranes. Cetylpyridinium chlorideis also available in the form of throat lozenges and amouthwash at a 1:20,000 dilution.
Safety ProfilePoison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by skin contact. A skin and eye irritant. When E heated to decomposiuon it emits very toxic fumes of NOx and Cl-.
SafetyCetylpyridinium chloride is used widely in mouthwashes as a bactericidal antiseptic. It is generally regarded as a relatively nontoxic material when used at a concentration of 0.05% w/v, although minor side effects such as mild burning sensations on the tongue have been reported.
At higher concentrations, cetylpyridinium chloride may damage the mucous membranes in the mouth. It is harmful when ingested or inhaled. It can cause eye irritation, and is irritant to the respiratory system and the skin.
LD50 (rat, IP): 0.006 g/kg
LD50 (rat, IV): 0.03 g/kg
LD50 (rat, oral): 0.2 g/kg
LD50 (rat, SC): 0.25 g/kg
LD50 (mouse, IP): 0.01 g/kg
LD50 (mouse, oral): 0.108 g/kg
LD50 (rabbit, oral): 0.4 g/kg
LD50 (rabbit, IV): 0.036 g/kg
storageCetylpyridinium chloride is stable under normal conditions. It should be stored in well-closed containers.
IncompatibilitiesIncompatible with strong oxidizing agents and bases. It is also incompatible with methylcellulose.
Magnesium stearate suspensions in cetylpyridinium chloride have been shown to significantly reduce its antimicrobial activity. This is due to the absorption of cetylpyridinium chloride on magnesium stearate. The cetylpyridinium chloride ion also interacts with gelatin, resulting in reduced bioavailability.
Regulatory StatusIncluded in nonparenteral formulations licensed in the UK. Included in the FDA Inactive Ingredients Database, for use in inhalation and oral preparations. Reported in the EPA TSCA Inventory. It is not approved for use in Japan. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Cetylpyridinium chloride Preparation Products And Raw materials
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