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DEXAMETHASONE SODIUM PHOSPHATE

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Products Intro: Product Name:DEXAMETHASONE SODIUM PHOSPHATE
CAS:312-93-6
Purity:0.99 Package:5KG;1KG
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Products Intro: Product Name:Dexamethasone phosphate;Hexadrol phosphate;EGP437;Neodecadron;EGP 437;EGP-437
CAS:312-93-6
Package:1 g;200 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:DEXAMETHASONE SODIUM PHOSPHATE
CAS:312-93-6
Purity:95.0% windy 126
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Products Intro: Product Name:DEXAMETHASONE SODIUM PHOSPHATE USP/EP/BP
CAS:312-93-6
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
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Products Intro: Product Name:DEXAMETHASONE SODIUM PHOSPHATE
CAS:312-93-6
Purity:99.9% Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer

DEXAMETHASONE SODIUM PHOSPHATE manufacturers

DEXAMETHASONE SODIUM PHOSPHATE Basic information
Product Name:DEXAMETHASONE SODIUM PHOSPHATE
Synonyms:(11β,16α)-9-Fluoro-11,17-dihydroxy-16-Methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione;Dexamethasone Phosphate (200 mg)K0E2750.996mg/mg(dr);,21-(dihydrogenphosphate);betnelanphosphate;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] dihydrogen phosphate;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-3-keto-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] dihydrogen phosphate;Dexamethasone Phosphate (200 mg)
CAS:312-93-6
MF:C22H30FO8P
MW:472.44
EINECS:206-232-0
Product Categories:Drug Analogues;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Organics
Mol File:312-93-6.mol
DEXAMETHASONE SODIUM PHOSPHATE Structure
DEXAMETHASONE SODIUM PHOSPHATE Chemical Properties
Melting point 154-157°C
Boiling point 669.6±65.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
pka1.67±0.10(Predicted)
form Solid
color White to Light Brown
Stability:Hygroscopic, Moisture Sensitive
Safety Information
Hazard Codes Xn
Risk Statements 62
HS Code 2937220000
Toxicitydni-rat-ipr 3 mg/kg JOENAK 62,527,74
MSDS Information
DEXAMETHASONE SODIUM PHOSPHATE Usage And Synthesis
OriginatorDecadron Phosphate,MS and D,US,1959
UsesA pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.
DefinitionChEBI: A steroid phosphate that is the 21-O-phospho derivative of dexamethasone.
Manufacturing ProcessA solution of bis-triethylamine phosphate was prepared by slowly adding 2.36 ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml of triethylamine at 20°C. This solution was added to a stirred solution of 4.70 g of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,2-dione 21- methanesulfonate and 20 ml of acetonitrile. The mixture was heated under reflux for four hours and then evaporated under reduced pressure to a volume of 12 ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21- trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate triethylamine salt with some inorganic phosphate.
The mixture was cooled, 25 ml of methanol added, and the cooled mixture treated with 33 ml of 1.89 N methanolic sodium methoxide solution. The precipitated inorganic phosphates were removed by suction filtration and washed thoroughly with methanol. The combined filtrates were evaporated under reduced pressure to a volume of 12 ml and treated with 30 ml of methanol. The resulting cloudy solution was clarified by filtration through diatomaceous earth. The volume of the filtrate was brought to 40 ml by the addition of methanol, and 120 ml of ether was added with stirring. The precipitated product, which was 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl1,4-pregnadiene-3,20-dione 21-phosphate sodium salt, was collected by suction filtration, and washed with acetone and then with ether. The weight of the air-dried material was 3.06 g.
Brand nameDecadron (Merck); Dexacen (Cent); Dexacort (UCB); Dexair (Pharmafair); Hexadrol (Organon); Maxidex (Alcon).
Therapeutic FunctionGlucocorticoid
Safety ProfileAn experimental teratogen. Otherexperimental reproductive effects. Mutation data reported.When heated to decomposition it emits toxic fumes of F-and POx.
DEXAMETHASONE SODIUM PHOSPHATE Preparation Products And Raw materials
Raw materialsSodium Methoxide-->Triethylamine-->Phosphoric acid
Tag:DEXAMETHASONE SODIUM PHOSPHATE(312-93-6) Related Product Information
Desoximetasone Dexamethasone 21-phosphate disodium salt Dexamethasone palmitate Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-[(3-sulfobenzoyl)oxy]-, monosodium salt, (11beta,16alpha)- Dexamethasone dipropionate 9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate Dexamethasone 9,11-epoxide 1,2-Dihydro DesoxyMetasone Dexamethasone Impurity I Dexamethasone EP Impurity E DexaMethasone β-D-Glucuronide SodiuM Salt Dexamethasone-d5 Dexamethasone 21-Propionate PSXDNQUHAFMVPT-NWQAGDSVSA-N Dexamethasone-17,20 21-Aldehyde dexamethasone 21-pivalate dexamethasone 21-(3-phenylpropionate) Dexamethasone 17-propionate