促肾上腺皮质激素-(11-24)-十四肽
| 中文名称 | 促肾上腺皮质激素-(11-24)-十四肽 |
|---|---|
| 中文同义词 | 促肾上腺皮质激素-(11-24)-十四肽;促肾上腺皮质激素肽11-21;KP-14 |
| 英文名称 | ADRENOCORTICOTROPIC HORMONE, FRAGMENT 11-24 |
| 英文同义词 | adrenocorticotropic hormone fragment 11-24, human;alpha11-24-ACTH;beta11-24-ACTH;Corticotropin-(11-24)-tetradecapeptide;Human ACTH(11-24);(11-24)-ACTH;α11-24-Corticotropin;Adrenocorticotropic Hormone (11-24) |
| CAS号 | 4237-93-8 |
| 分子式 | C77H134N24O16 |
| 分子量 | 1652.04 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 4237-93-8.mol |
| 结构式 |  |
促肾上腺皮质激素-(11-24)-十四肽 性质
| 储存条件 | Store at -20°C, protect from light, stored under nitrogen |
|---|---|
| 形态 | 固体 |
| 水溶解性 | Soluble in Water |
ACTH (11-24) 是促肾上腺皮质激素的多肽片段，为促肾上腺皮质激素 (ACTH) 受体拮抗剂，能够促进皮质醇的释放。
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
Adrenocorticotropic hormone receptor
ACTH (11-24) acts as an antagonist of adrenocorticotropic hormone receptor. ACTH (11-24) induces cortisol secretion submaximally in freshly dispersed or cultured beef adrenal cortical cells. The maximal cortisol release by ACTH (11-24) is enhanced by forskolin but inhibited by calcium channel blockers.
ACTH (11-24) blocks electroacupuncture (EA) anti-edema but not EA anti-hyperalgesia in rats.
参考质量标准
外观性状:白色粉末纯度(HPLC):≥98.0%醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%