ACTH (1-17)
| 中文名称 | ACTH (1-17) |
|---|---|
| 中文同义词 | ALPHA1-17-促肾上腺皮质激素;促肾上腺皮质激素片段 (1-17),人;促肾上腺皮质激素片段 (1-17),人, ≥97% (HPLC);人ACTH (1-17)肽;促肾上腺皮质激素ACTH(1-17), HUMAN;促肾上腺皮质激素Α1-17-ACTH;ALPHA1-17-促肾上腺皮质激素;促肾上腺皮质激素片段 1-17 |
| 英文名称 | ACTH (1-17) |
| 英文同义词 | H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-OH;ACTH (1-17);ACTH (1-17), HUMAN;ADRENOCORTICOTROPIC HORMONE FRAGMENT 1-17;ADRENOCORTICOTROPIC HORMONE (1-17), HUMAN;ADRENOCORTICOTROPIC HORMONE (1-27);ADRENOCORTICOTROPIC HORMONE HUMAN FRAGMENT 1-17;SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG |
| CAS号 | 7266-47-9 |
| 分子式 | C95H145N29O23S |
| 分子量 | 2093.41 |
| EINECS号 | |
| 相关类别 | 多肽;细胞生物学;细胞信号和神经生物学;Peptides for Cell Biology;Pituitary Hormones;Peptide;Adrenocorticotrophic Hormone (ACTH)Peptides and Proteins;Adrenocorticotropic Hormones (ACTH);Hormones |
| Mol文件 | 7266-47-9.mol |
| 结构式 |  |
ACTH (1-17) 性质
| 密度 | 1.48±0.1 g/cm3(Predicted) |
|---|---|
| RTECS号 | GM7907000 |
| 储存条件 | −20°C |
| 形态 | 冻干粉 |
| 水溶解性 | Soluble in Water |
Ki: 0.21 nM (human MC1 receptor)
ACTH (1-17) is a potent agonist at the hMC1R. ACTH (1-17) shows high affinity for the hMC1R with a K i value of 0.21±0.03 nM which is slightly higher than that of 0.13±0.005 nM for alpha-MSH. ACTH (1-17) induces a slight and not significant increase in growth hormone secretion even when micromolar concentrations of the peptide are employed in rat pituitary cultures.
Inhibition of DNA labeling is noted when the ACTH (1-17) is administered at 2 hr after the beginning of the daily dark span when nocturnal animals become active. When administered at this circadian stage, the larger dose in particular is associated with an inhibition of DNA labeling lasting for 24 hr. The inhibitory effect is much shorter when the same dose is injected 4 hr earlier.
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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