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Triamterene

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CAS:396-01-0
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CAS:396-01-0
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Products Intro: Product Name:Triamterene
CAS:396-01-0
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Products Intro: Product Name:Triamterene
CAS:396-01-0
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg

Lastest Price from Triamterene manufacturers

  • Triamterene
  • US $2.00 / kg
  • 2019-07-06
  • CAS:396-01-0
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: ask
Triamterene Basic information
Product Name:Triamterene
Synonyms:7-pteridinetriamine,6-phenyl-4;diren;ditak;diurene;dyren;dyrenium;6-PHENYL-PTERIDINE-2,4,7-TRIAMINE;6-PHENYL-2,4,7-PTERIDINETRIAMINE
CAS:396-01-0
MF:C12H11N7
MW:253.26
EINECS:206-904-3
Product Categories:Nucleotides;DYRENIUM;Intermediates & Fine Chemicals;Pharmaceuticals;Ion transporter and other ion channel;Other APIs;Aromatics;Bases & Related Reagents
Mol File:396-01-0.mol
Triamterene Structure
Triamterene Chemical Properties
Melting point 316°C
Boiling point 386.46°C (rough estimate)
density 1.3215 (rough estimate)
refractive index 1.8260 (estimate)
Fp 11 °C
storage temp. 2-8°C
solubility formic acid: soluble200 mg + 4 mL warm Formic Acid, clear, yellow-green
form neat
pka6.2(at 25℃)
Water Solubility <0.1 G/100 ML AT 20 ºC
Merck 14,9599
BRN 266723
InChIKeyFNYLWPVRPXGIIP-UHFFFAOYSA-N
CAS DataBase Reference396-01-0(CAS DataBase Reference)
NIST Chemistry ReferenceTriamterene(396-01-0)
EPA Substance Registry SystemTriamterene (396-01-0)
Safety Information
Hazard Codes Xn,T,F
Risk Statements 22-36/37/38-36/38-23/25-39/23/24/25-23/24/25-11
Safety Statements 26-36/37/39-45-33-24-16-7-36/37
RIDADR 2811
WGK Germany 3
RTECS UO3470000
HazardClass 6.1(b)
PackingGroup III
HS Code 2933997500
Hazardous Substances Data396-01-0(Hazardous Substances Data)
MSDS Information
ProviderLanguage
2,4,7-Triamino-6-phenylpteridine English
SigmaAldrich English
ALFA English
Triamterene Usage And Synthesis
Chemical PropertiesYellow Solid
UsesTriamterene is a weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.
UsesTriamterene is a potassium-sparing diuretic ie, it inhibits the urinary excretion of potassium
Biological FunctionsTriamterene (Dyrenium) results in changes in urinary electrolyte patterns that are qualitatively similar to those produced by spironolactone. The mechanism by which this agents bring about the alterations in electrolyte loss, however, is quite different. Triamterene produces this effects whether or not aldosterone or any other mineralocorticoid is present. The action of this drug is clearly unrelated to endogenous mineralocorticoid activity, and this drug is effective in adrenalectomized patients.
General DescriptionOdorless yellow powder or crystalline solid. Melting point 316°C. Almost tasteless at first and with a slightly bitter aftertaste. Acidified solutions give a blue fluorescence. Used as a diuretic drug.
Air & Water ReactionsSensitive to light; slowly oxidized upon exposure to air. Insoluble in water.
Reactivity Profile2,4,7-Triamino-6-phenylpteridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Fire HazardFlash point data for 2,4,7-Triamino-6-phenylpteridine are not available; however, 2,4,7-Triamino-6-phenylpteridine is probably combustible.
Clinical UseTriamterene can be used in the treatment of congestive heart failure, cirrhosis, and the edema caused by secondary hyperaldosteronism. It is frequently used in combination with other diuretics except spironolactone. Amiloride, but not triamterene, possesses antihypertensive effects that can add to those of the thiazides. These K+-sparing diuretics have low efficacy when used alone, since only a small amount of total Na reabsorption occurs at more distal sites of the nephron.
These compounds are used primarily in combination with other diuretics, such as the thiazides and loop diuretics, to prevent or correct hypokalemia. The availability of fixed-dose mixtures of thiazides with nonsteroidal K+-sparing compounds has proved a rational form of drug therapy. Both triamterene and amiloride are available alone or in combination with hydrochlorothiazide.
Side effectsBecause the actions of triamterene and amiloride are independent of plasma aldosterone levels, their prolonged administration is likely to result in hyperkalemia. Both amiloride and triamterene are contraindicated in patients with hyperkalemia.Triamterene should not be given to patients with impaired renal function. Potassium intake must be reduced, especially in outpatients.A folic acid deficiency has been reported to occur occasionally following the use of triamterene.
Veterinary Drugs and TreatmentsTriamterene is a potassium-sparing diuretic that potentially could be used as an alternative to spironolactone for the adjunctive treatment of congestive heart failure in dogs, however, there is little experience associated with its use in dogs or cats.
Triamterene Preparation Products And Raw materials
Raw materialsEthyl cyanoacetate-->Sodium ethoxide-->Disodium edetate dihydrate-->phenylacetonitrile-->2,4,6-Triaminopyrimidine
Tag:Triamterene(396-01-0) Related Product Information
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