Company Name: |
Sigma-Aldrich
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Tel: |
021-61415566 800-8193336 |
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orderCN@merckgroup.com |
Products Intro: |
Product Name:BV02 CAS:292870-53-2 Purity:>=98% (HPLC) Package:25MG Remarks:SML0140-25MG
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Company Name: |
ShangHai Biochempartner Co.,Ltd
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Tel: |
17754423994 17754423994 |
Email: |
2853530910@QQ.com |
Products Intro: |
Product Name:BV02 CAS:292870-53-2 Purity:98% HPLC LCMS Package:100mg;500mg;1g
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| 2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Basic information |
Product Name: | 2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID | Synonyms: | TOSLAB 796846;2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID;2-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid;BV02;2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid;BV02 >=98% (HPLC);1H-Isoindole-5-carboxylic acid, 2-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo- | CAS: | 292870-53-2 | MF: | C20H15N3O5 | MW: | 377.35 | EINECS: | | Product Categories: | | Mol File: | Mol File | |
| 2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Chemical Properties |
Boiling point | 593.8±60.0 °C(Predicted) | density | 1.512±0.06 g/cm3(Predicted) | storage temp. | room temp | solubility | DMSO: >5mg/mL | pka | 3.39±0.20(Predicted) | form | powder | color | white to off-white |
Hazard Codes | N | Risk Statements | 50 | Safety Statements | 61 | RIDADR | UN 3077 9 / PGIII | WGK Germany | 3 |
| 2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Usage And Synthesis |
Uses | BV02 has been used to study the effects of 14-3-3σ on P-glycoprotein and pregnane X receptor protein xpression. It has also been used as a control in studying BAP1 (BRCA1 (breast cancer gene)-associated protein 1) inducing cell death via interaction with 14-3-3 in neuroblastoma. | Biochem/physiol Actions | BV02 is an inhibitor of the 14-3-3 scaffolding proteins docking site. BV02 promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation. It induces apoptosis by c-Abl release from 14-3-3? and re-location to nuclear compartment and at mitochondrial membranes. |
| 2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Preparation Products And Raw materials |
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