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Protoporphyrin IX

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Products Intro: Product Name:Protoporphyrin IX
CAS:553-12-8
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
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Products Intro: CAS:553-12-8
Purity:95% Package:g-Kg
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Products Intro: Product Name:Protoporphyrin IX
CAS:553-12-8
Purity:>97% Package:1g;250mg
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Products Intro: Product Name:Protoporphyrin IX
CAS:553-12-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Protoporphyrin IX Basic information
Product Name:Protoporphyrin IX
Synonyms:PROTOPORPHYRIN-'IX';(SP-4-2)-[7,12-DIETHENYL-3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPANOATO(4-)-N21,N22,N23,N24]-DIHYDROGEN ZINCATE(2-);ZNPP-9;ZN(II) PROTOPORPHYRIN IX;ZINC(II) PROTOPORPHYRIN IX;ZINC PROTOPORPHYRIN;ZINC PROTOPORPHYRIN-9;ZINC PROTOPORPHYRIN IX
CAS:553-12-8
MF:C34H34N4O4
MW:562.66
EINECS:209-033-7
Product Categories:Natural Porphyrins and Derivitives;Porphyrins;porphine (porphyrin) ligand;Inhibitors
Mol File:553-12-8.mol
Protoporphyrin IX Structure
Protoporphyrin IX Chemical Properties
Boiling point 629.06°C (rough estimate)
density 1.1829 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. 2-8°C
form Powder
color purple
Sensitive light sensitive
Merck 13,7990
BRN 380795
InChIKeyFEDYMSUPMFCVOD-UJJXFSCMSA-N
CAS DataBase Reference553-12-8
NIST Chemistry ReferenceProtoporphyrin-1x(553-12-8)
EPA Substance Registry System21H,23H-Porphine- 2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl- (553-12-8)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
8-10-23
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
Protoporphyrin IX Usage And Synthesis
Useshepatoprotectant
DefinitionChEBI: A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyri s.
Enzyme inhibitorThis iiron-free, immediate precusor of heme (FWfree-acid = 562.67 g/mol; CAS 553-12-8; brownish-yellow solid; soluble in a number of organic solvents; disodium and dipotassium salts solublized in the presence of Tween 80) has lmax values in 25% HCl are 602.4, 582.2, and 557.2 nm. Protoporphryrin IX is also an activator of guanylate cyclase. See also Iron Protoporphyrin IX; Heme; HTeamrignet (s) : aminolevulinate aminotransferase; 5-aminolevulinate synthase; glutamate: glyoxylate aminotransferase; glutathione S-transferase (7-10); glyoxalase I, or lactoylglutathione lyase; guanylate cyclase; heme oxygenase; hydroxymethylbilane synthase, or porphobilinogen deaminase; nitric-oxide synthase; porphobilinogen synthase, or 5-aminolevulinate dehydratase; succinyl-CoA synthetase; tryptophan pyrrolase, or tryptophan 2,3-dioxygenase; and uroporphyrinogen decarboxylase.
Purification MethodsProtoporphyrin IX (3,18-divinyl-2,7,13,17-tetramethylporphin-8,12-dipropionic acid, ooporphyrin) [553-12-8] M 562.7, pKEst ~ 4.8. Protoporphyrin IX is purified by dissolving (4g) in 98-100% HCOOH (85mL), diluting with dry Et2O (700mL) and keeping at 0o overnight. The precipitate is collected and washed with Et2O, then H2O, and dried in a vacuum at 50o over P2O5. It crystallises from aqueous pyridine and from Et2O in monoclinic, brownish-yellow prisms. The UV max values in 25% HCl are 557.2, 582.2 and 602.4nm. It is freely soluble in ethanolic HCl, AcOH, CHCl3, and Et2O containing AcOH. It forms sparingly soluble diNa and diK salts. [Ramsey Biochemical Preparations 3 39 1953, UV: Holden Aust J. Exptl Biol and Med Sci 15 412 1937, Garnick J Biol Chem 175 333 1948, IR: Falk & Willis Aust J Sci Res [A] 4 579 1951, Beilstein 26 IV 3042.]
Protoporphyrin IX Preparation Products And Raw materials
Tag:Protoporphyrin IX(553-12-8) Related Product Information
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