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Baicalein

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Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:Baicalein
CAS:491-67-8
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
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Products Intro: Product Name:Bupleurum distillates
CAS:491-67-8
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Products Intro: Product Name:Baicalein
CAS:491-67-8
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: CAS:491-67-8
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
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Products Intro: Product Name:Baicalein
CAS:491-67-8

Lastest Price from Baicalein manufacturers

  • Baicalein
  • US $2.00 / KG
  • 2019-05-13
  • CAS:491-67-8
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1 ton
  • Baicalein
  • US $1.00 / KG
  • 2019-05-13
  • CAS:491-67-8
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
Baicalein Basic information
Product Name:Baicalein
Synonyms:Baicalein - CAS 491-67-8 - Calbiochem;BAICALEIN(SH)NOW RG GRADE;Baicalein, monohydrate, 5,6,7-Trihydroxy-2-phenyl-4H-chromen-4-one monohydrate;Baicelein;Noroxylin;5,6,7-trihydroxy-2-phenyl-4H-chroMen-4-one;Baicalein 98%;5,6,7-trihydroxy-2-phenyl-4-chromenone hydrate
CAS:491-67-8
MF:C15H10O5
MW:270.24
EINECS:
Product Categories:-;Aromatics;Heterocycles;API;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Tri-substituted Flavones;The group of Scutellaria;Inhibitors
Mol File:491-67-8.mol
Baicalein Structure
Baicalein Chemical Properties
Melting point 256-271 °C(lit.)
Boiling point 373.35°C (rough estimate)
density 1.3280 (rough estimate)
refractive index 1.5000 (estimate)
storage temp. 2-8°C
form Yellow solid
Merck 14,942
BRN 272683
CAS DataBase Reference491-67-8(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-20/21/22
Safety Statements 26-36
WGK Germany 3
RTECS DJ3100898
Hazard Note Irritant
HS Code 29329990
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
Baicalein Usage And Synthesis
Chemical PropertiesYellow Crystalline Solid
UsesBaicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. Several different functions of baicalein have been reported. Platelet 12-lipoxygenase is inhibited by baicalein with an ID50 value of 0.12 μM, with minimal inhibition of platelet cyclooxygenase-1 (IC50 = 0.83 mM). Baicalein inhibits lipid peroxidation, as assessed by production of TBARS, with an IC50 value of 5 μM. In addition to these effects, baicalein may play a role in apoptosis, as the compound inhibits cell growth of three human hepatocellular carcinoma cell lines with IC50 values ranging from 17-70 μg/ml.
Usesantiviral (HIV)
UsesAn inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis. Baicalein is the fl avonoid component of Nepalese and Sino-Japanese crude drugs.
Usesinhibitor of lipoxidase and leukotriene biosynthesis
UsesAn inhibitor of Ca2+ uptake, 5-LO, and 12-LO
DefinitionChEBI: A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.
Biological ActivityInhibitor of 5- and platelet 12-lipoxygenases (IC 50 values are 9.5 and 0.12 mM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Anti-inflammatory in vivo .
Enzyme inhibitorThis flavone (FW = 270.24 g/mol; CAS 491-67-8), also known as 5,6,7- trihydroxy-2-phenyl-chromen-4-one, is formed upon metabolic hydrolysis of baicalin, a flavone prodrug found in the Chinese medicinal herb Huang-chin(See Baicalin). It inhibits leukotriene biosynthesis and is also a free radical scavenger. Alkaline solutions have a greenish-brown color, while strong acidic solutions are yellow with a green fluorescence. Baicalein inhibits CYP2C9 (Ki ≈ 2 μM), a cytochrome P450 that metabolizes many drugs, including NSAIDs (Celecoxib, Ibuprofen, Naproxen), Sulfonylureas (Glipizide, Glibenclamide, Glimepiride), Angiotensin II receptor antagonists (Irbesartan and Losartan), Warfarin, Sildenafil, and Tamoxifen. Target(s): 12-lipoxygenase, or arachidonate 12-lipoxygenase, Ki = 0.14 μM (1,13,43- 48); 17b-hydroxysteroid dehydrogenase; NADP+-dependent malic enzyme; phosphoenolpyruvate carboxylase; thyroid type I deiodinase; steroid 5a-reductase; aromatase, or CYP19; RNA directed DNA polymerase; aldose reductase; 5-lipoxygenase, or arachidonate 5 lipoxygenase; aryl hydrocarbon hydroxylase, unspecific monooxygenase; sialidase, mouse liver; NAD(P)H dehydrogenase, or DT-diaphorase; DNA polymerase g; DNA polymerase I, Escherichia coli; hyaluronidase; xanthine oxidase; UDP glucuronosyltransferase; a-glucosidase, or sucrase; Raf-1 protein kinase; integrase, HIV-1; CYP3A4, or testosterone 6b-hydroxylation; CYP1A2, caffeine N'-demethylation; VHR dual-specificity protein-tyrosine phosphatase; 15- lipoxygenase, or arachidonate 15-lipoxygenase; Ki = 0.18 μM; lipoxygenase, soybean; protein kinase CK2; lactoylglutathione lyase, or glyoxalase I; membrane alanyl aminopeptidase, or aminopeptidase N; DNA-directed DNA polymerase; inositol trisphosphate 3-kinase; glycogen phosphorylase; fatty-acid synthase; 1-alkylglycerophosphocholine O-acetyltransferase; tyrosinase, monophenol monooxygenase; 8-lipoxygenase, or arachidonate 8-lipoxygenase.
Baicalein Preparation Products And Raw materials
Tag:Baicalein(491-67-8) Related Product Information
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