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2-Butanol

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Products Intro: Product Name:sec-Butanol
CAS:78-92-2
Purity:99% Package:16/KG
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Products Intro: Product Name:2-Butanol
CAS:78-92-2
Purity:99% Package:100g,500g,1kg,5kg,10kg
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Products Intro: CAS:78-92-2
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Products Intro: Product Name:sec-Butanol
CAS:78-92-2
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Products Intro: Product Name:2-Butanol
CAS:78-92-2
Purity:99.9% Package:1KG;6USD
2-Butanol Chemical Properties
Melting point −115 °C(lit.)
Boiling point 98 °C(lit.)
density 0.808 g/mL at 25 °C(lit.)
vapor density 2.6 (vs air)
vapor pressure 12.5 mm Hg ( 20 °C)
refractive index n20/D 1.397(lit.)
Fp 80 °F
storage temp. Flammables area
solubility 125g/l
form Liquid
color Colorless
OdorStrong, pleasant.
Relative polarity0.506
explosive limit1.4-9.8%(V)
Water Solubility 12.5 g/100 mL (20 ºc)
Sensitive Hygroscopic
Merck 14,1541
BRN 1718765
Stability:Stable. Flammable. Substances to be avoided include acids, acid chlorides, acid anhydrides, oxidizing agents and halogens.
InChIKeyBTANRVKWQNVYAZ-UHFFFAOYSA-N
CAS DataBase Reference78-92-2(CAS DataBase Reference)
NIST Chemistry Reference2-Butanol(78-92-2)
EPA Substance Registry System2-Butanol(78-92-2)
Safety Information
Hazard Codes Xi
Risk Statements 10-36/37-67
Safety Statements 13-24/25-26-46-7/9
RIDADR UN 1120 3/PG 3
WGK Germany 1
RTECS EO1750000
Autoignition Temperature761 °F
TSCA Yes
HazardClass 3
PackingGroup II
HS Code 29051490
Hazardous Substances Data78-92-2(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 6480 mg/kg LD50 dermal Rat > 2000 mg/kg
MSDS Information
ProviderLanguage
sec-Butyl alcohol English
SigmaAldrich English
ACROS English
ALFA English
2-Butanol Usage And Synthesis
Physical and Chemical Properties2-butanol is also known as 2-butanol, methyl ethyl alcohol, chemical formula is CH3CH2CHOHCH3. Molecular weight is 74.12. It is colorless liquid with a strong aroma of mint, flammable, volatile, with optical activity. The molecule has a chiral carbon atom, can be present in three forms of right-handed body, left-handed body and racemic body, dl-body: the relative density is 0.8063. Melting point is-114.7 ℃. Boiling point is 99.5 ℃, 45.5 ℃ (7.999 × 103Pa). The flash point is 34 ℃. The refractive index is 1.3978. d-body: the relative density is 0.8080. Boiling point is 99.5 ℃. The flash point is 24 ℃. The refractive index is 1.3954. Specific rotation is + 13.9 °. l-body: the relative density is 0.8070. Boiling point is 99.5 ℃. The flash point is 28 ℃. The refractive index is 1.3955. Specific rotation is-13.51 ° (25 ℃). 2-butanol oxidation can generate methyl ethyl ketone and acetic acid. Slightly soluble in water (25 ℃ when 12.5ml/100ml), dissolved in acetone, benzene, miscible with ethanol and ether. This product interacts with water to form an azeotropic mixture, the product content is 68%, the total boiling point is 88.5 ℃. Rat oral is LD506480mg/kg. 2-butanol is the main raw material for producing methyl ethyl ketone, butyl acetate, sec-butyl acetate, and also used as a solvent and extraction agent, the raw materials of plasticizers, processing agents, herbicides, but also for synthesis of spices, flavors, coloring agents, wetting agent, cleaning agents and solvents of many natural resin, linseed oil and castor oil.
Chemical PropertiesIt is slightly sticky colorless flammable liquid, with a strong odor. Melting point is-114.7 ℃, the boiling point is 99.5 ℃, relative density (d204) is 0.808~0.809, the refractive index (nD25) is 1.3949, a flash point is 23.9 ℃. It is soluble in water, miscible in ethanol and ether.
Uses1. Used as extraction solvent, spices.
2. 2-butanol is Used as a solvent, and chromatography reagents
3. 2-butanol is Used for the production of intermediates of methyl ethyl ketone, for the preparation of butyl acetate, sec-butyl, used as plasticizers, processing agents, herbicides, solvents and so on.
4. Used for the production of intermediates of methyl ethyl ketone, for the preparation of butyl acetate, sec-butyl.
Butanol isomersButanol is an important industrial raw material, also known as hydroxy butane, a monohydric alcohol, the lowest level alcohol for the same family which can have two or more isomers, butanol has four kinds of isomers, namely n-butanol, 2-butanol, tert-butanol and isobutanol. Relative molecular mass is 74.12. Butanol has the common property of alcohols, such as water-like, reacts with metal to produce alkoxide, reacts with halogen acid to produce halogenated hydrocarbons, dehydrates into alkenes, oxidation (or dehydrogenation) reaction to produce aldehydes and acids, and reacts with organic acids or oxygen-containing inorganic acid to generate ester and so on. In the four isomers, the toxicity of n-butanol is minimal, the toxicity of the other three is not large, but their irritation is great, with irritation to the skin and mucous membrane. Inhalation of large vapors can cause coma. The maximum allowable concentration at workplace is 100 × 10-6. Butanol can be directly used as a solvent, extraction agent, dehydrating agent, plasticizer, mineral processing agent, anti-aging agent, herbicide and so on.
Physical and chemical properties and toxicity of butanol are different due to isomers. The solubility in water depends on their structure, chemical properties depend on hydroxy location in alcohol: n-butanol and iso-butanol are primary alcohols, can be oxidized into the corresponding aldehyde or acid, sec-butyl alcohol is oxidized into the corresponding ketone, t-butanol is unsusceptible to oxidation.
Physicochemical properties comparison chart of 4 isomers of butanol
Physicochemical properties comparison chart of 4 isomers of butanol
Under dehydrating catalyst, butanol can produce butene, n-butanol and 2-butene can give 1-butene, 2-butene, 2-butanol can generate 2-butene, isobutanol and tert-butanol generate isobutylene. Under the catalyst of copper and silver, the dehydrogenation generates carbonyl compounds, n-butanol generates butyraldehyde, butanol generates methyl ethyl ketone, isobutanol generate isobutyraldehyde. Under the catalyst, air oxidation can generate acid. Catalyzed by a mineral acid, it reacts with organic acid to generate ester. Reaction with benzene, can generate butyl benzene. Butanol reacts with chlorine to generate butyraldehyde chloride. Under the action of the aluminum catalyst at 300~350 ℃, reacts with ammonia, n-butanol, iso-butanol and 2-butanol react with ammonia to generate butylamine, dibutylamine, tributylamine, t-butanol does not have this character. N-butanol and tert-butanol at 180 ℃ react with hydrogen sulfide to generate butyl mercaptan.
The above information were collated and edited by Xiaonan of Chemicalbook.
Laboratory method for preparing 2-butanol1, As raw materials 2-butene reacts with sulfuric acid in concentrated sulfuric acid to produce sulfuric acid butyl ester, sulfuric acid ester is then hydrolyzed to produce 2-butanol, and then distillation purification.
Butanol is prepared from 2-butene as raw material
2, 2-butanone is used as raw material, under the action of a Grignard reagent, to prepare 2-butanol.
3, cis-2-butene is used as raw material, under the action of boron hydrides, to prepare d-or l-body.
Production methodAfter adsorption by butane of the cracking petroleum or natural gas in sulfuric acid, then hydrolyze with steam.
Dangerous situationsProlonged inhalation is toxic, it irritates eye and skin. Flammable, flash point is 406 ℃, there is a greater risk of combustion. The allowable concentration in air of US is 100ppm (305mg/m3).
IncompatibilitySec-butyl alcohol is incompatible with strong oxidizing agents.
StorageIt is Stored in metal drums, to prevent mechanical damage, best stored in a cool, dry and ventilated, non-flammable place, away from all possible sources of ignition, separated from strong oxidants.
Transport requirementsDuring transportation, "flammable liquid" shall be marked logo on the container. Others should be the same with "n-butanol".
Extinguish measuresWhen firing, dry powder fire extinguishing agent, fire-resistant foam or CO2 can be used. Water fighting is invalid, but spray with water in the fire container to keep it cool. If spills, and spills are not lighted, water mist can wash spray spills from the fire, and dilute to non-flammable mixtures. If necessary, water mist can be used to protect the operator to stop the leakage. Other items see the "n-butanol."
Hazards & Safety InformationCategory: Flammable liquid
Toxicity grading: Poisoning
Acute toxicity
Oral-rat LD50: 6480 mg/kg, Intravenous-Mouse LD50: 764 mg/kg
Stimulus data
Eyes-rabbit 100 mg/24 hours    moderate, Skin-rabbit 500 mg/24 hr  mild
Hazardous characteristics
It is explosive when mixed with air, self-oxidized to form explosive peroxides.
Flammability hazard characteristics
in case of fire, high temperature, oxidant, it is flammable, burning to generate irritation smoke, spontaneous combustion in contact with chromium trioxide.
Storage characteristics
Treasury ventilation low-temperature drying, and it is stored from oxidants.
Extinguishing agent
Dry powder, water spray, carbon dioxide, foam
Professional standards
TWA 100 PPM (310 mg/m3)
Chemical PropertiesColourless liquid
UsesPreparation of methyl ethyl ketone, sol- vent, organic synthesis, paint removers, industrial cleaners.
DefinitionChEBI: A secondary alcohol that is butane substituted by a hydroxy group at position 2.
General DescriptionA clear colorless liquid with an alcohol odor. Flash point below 0 °F. Less dense than water. Vapors heavier than air. Soluble in water. Moderately irritates the eyes and skin. Prolonged and repeated contact may cause defatting and drying of the skin. Vapors may irritate the nose, throat and respiratory tract. May be harmful by ingestion.
Air & Water ReactionsHighly flammable. Soluble in water.
Reactivity ProfileAttacks plastics. [Handling Chemicals Safely 1980. p. 236]. Acetyl bromide reacts violently with alcohols or water (Merck 11th ed. 1989). Mixtures of alcohols with concentrated sulfuric acid and strong hydrogen peroxide can cause explosions. Example: An explosion will occur if dimethylbenzylcarbinol is added to 90% hydrogen peroxide then acidified with concentrated sulfuric acid. Mixtures of ethyl alcohol with concentrated hydrogen peroxide form powerful explosives. Mixtures of hydrogen peroxide and 1-phenyl-2-methyl propyl alcohol tend to explode if acidified with 70% sulfuric acid [Chem. Eng. News 45(43):73 1967; J, Org. Chem. 28:1893 1963]. Alkyl hypochlorites are violently explosive. They are readily obtained by reacting hypochlorous acid and alcohols either in aqueous solution or mixed aqueous-carbon tetrachloride solutions. Chlorine plus alcohols would similarly yield alkyl hypochlorites. They decompose in the cold and explode on exposure to sunlight or heat. Tertiary hypochlorites are less unstable than secondary or primary hypochlorites [NFPA 491 M 1991]. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence [Wischmeyer 1969].
HazardToxic, mutagenic, upper respiratory tract irritant, central nervous system impairment.
Health HazardRecommended Personal Protective Equipment: Organic vapor canister or air-supplied mask; chemical goggles or face splash shield; Symptoms Following Exposure: Headache, dizziness, and respiratory irritation. Liquid is severely irritating to the eyes and may cause eyeburn; General Treatment for Exposure: INHALATION: remove from exposure immediately; call a physician; if breathing is irregular or has stopped, start resuscitation and administer oxygen. INGESTION: induce vomiting and call a physician. EYES: flush with water for at least 15 min.; Toxicity by Inhalation (Threshold Limit Value): 150 ppm; Short-Term Exposure Limits: 200 ppm for 60 min.; Toxicity by Ingestion: Grade 1; LD50 = 5-15 g/kg (rat-single oral dose); Late Toxicity: None; Vapor (Gas) Irritant Characteristics: Vapors cause a slight smarting of the eyes or respiratory system if present in high concentrations. The effect is temporary; Liquid or Solid Irritant Characteristics: No appreciable hazard. Practically harmless to the skin; Odor Threshold: Data not available.
Fire HazardFlash Point (°F): 15 ℃; Flammable Limits in Air (%): 1.7-9.0; Fire Extinguishing Agents: Carbon dioxide, dry chemical; Fire Extinguishing Agents Not To Be Used: Not pertinent; Special Hazards of Combustion Products: Not pertinent; Behavior in Fire: Not pertinent; Ignition Temperature (°F): 763; Electrical Hazard: Class I, Group D; Burning Rate: 3.1 mm/min.
Chemical ReactivityReactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Safety ProfilePoison by intravenous and intraperitoneal routes. Mildly toxic by ingestion. Experimental reproductive effects. A skin and eye irritant. See also nBUTYL ALCOHOL and ALCOHOLS. Dangerous fire hazard when exposed to heat or flame. Auto-oxidizes to an explosive peroxide. Ignites on contact with chromium trioxide. To fight fire, use water spray, alcohol foam, CO2, dry chemical. Incompatible with oxidizing materials. When heated to decomposition it emits acrid smoke and fumes.
Potential ExposureButyl alcohols are used as solvents for paints, lacquers, varnishes, natural and synthetic resins, gums, vegetable oils, dyes, camphor, and alkaloids. They are also used as an intermediate in the manufacture of pharmaceuticals and chemicals; in the manufacture of artificial leather, safety glass; rubber and plastic cements, shellac, raincoats, photographic films, perfumes; and in plastic fabrication.
First aidMove victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy
ShippingUN1120 Butanols, Hazard Class: 3; Labels: 3— Flammable liquid. UN1212 Isobutanol or Isobutyl alcohol, Hazard Class: 3; Labels: 3—Flammable liquid
Purification MethodsPurification methods are the same as for n-Butanol. These include drying with K2CO3 or CaSO4, followed by filtration and fractional distillation, refluxing with CaO, distillation, then refluxing with magnesium and redistillation, and refluxing with, then distilling from CaH2. Calcium carbide has also been used as a drying agent. The anhydrous alcohol is obtained by refluxing with sec-butyl phthalate or succinate. (For method see Ethanol.) Small amounts of alcohol can be purified via conversion to the alkyl hydrogen phthalate and recrystallisation [Hargreaves J Chem Soc 3679 1956]. For purification of optical isomers, see Timmermans and Martin [J Chem Phys 25 411 1928]. [Beilstein 2 III 1566.]
IncompatibilitiesButyl alcohols may form explosive mixture with air. In all cases they are Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks some plastics, rubber and coatings. n-Butanol is incompatible with strong acids; halogens, caustics, alkali metals; aliphatic amines; isocyanates. sec-Butanol forms an explosive peroxide in air. Ignites with chromium trioxide. Incompatible with strong oxidizers; strong acids; aliphatic amines; isocyanates, organic peroxides. tert-Butanol is incompatible with strong acids (including mineral acid), including mineral acids; strong oxidizers or caustics, aliphatic amines; isocyanates, alkali metals (i.e., lithium, sodium, potassium, rubidium, cesium, francium). isoButanol is incompatible with strong acids; strong oxidizers; caustics, aliphatic amines; isocyanates, alkali metals and alkali earth. May react with aluminum at high temperatur
Waste DisposalIncineration, or bury absorbed waste in an approved land fill.
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