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| | Beta-Neoendorphin Basic information |
| Product Name: | Beta-Neoendorphin | | Synonyms: | BETA-NEOENDORPHIN;BETA-NEO-ENDORPHIN (PORCINE);H-TYR-GLY-GLY-PHE-LEU-ARG-LYS-TYR-PRO-OH;PRODYNORPHIN (175-183) (HUMAN, PORCINE);TYR-GLY-GLY-PHE-LEU-ARG-LYS-TYR-PRO;B-neoendorphin;L-Tyr-Gly-Gly-L-Phe-L-Leu-L-Arg-L-Lys-L-Tyr-L-Pro-OH;TYR-GLY-GLY-PHE-LEU-ARG-LYS-TYR-PRO: YGGFLRKYP | | CAS: | 77739-21-0 | | MF: | C54H77N13O12 | | MW: | 1100.27 | | EINECS: | | | Product Categories: | | | Mol File: | 77739-21-0.mol |  |
| | Beta-Neoendorphin Chemical Properties |
| storage temp. | -15°C | | form | Solid | | color | White to off-white | | InChIKey | RTXIYIQLESPXIV-VLOLPVCOSA-N |
| | Beta-Neoendorphin Usage And Synthesis |
| Uses | β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9[1][2]. | | Definition |
Pro-dynorphin (also referred to as pro-enkephalin B) can be processed to produce dynorphin A, dynorphin B, α-neoendorphin, and β-neoendorphin. Beta-Neoendorphin is an endogenous opioid peptide. Beta-Neoendorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. It shows activation of the Erk1/2, MMP-2 and MMP-9. The carboxypeptidase cleavage step is not rate limiting for the production of most neuroendocrine peptides, the exceptions being the conversion of α-neoendorphin into β-neoendorphin, which requires cleavage of a Pro-Lys bond, and the generation of rat β-endorphin 1-26, which requires cleavage of a C-terminal His-27 residue.
| | IC 50 | ERK1; ERK2; MMP-2; MMP-9 | | References | [1] Minamino N, et al. Beta-neo-endorphin, a new hypothalamic "big" Leu-enkephalin of porcine origin: its purification and the complete amino acid sequence. Biochem Biophys Res Commun. 1981 Apr 15;99(3):864-70. DOI:10.1016/0006-291x(81)91243-2
[2] Yang DJ, et al. β-Neoendorphin Enhances Wound Healing by Promoting Cell Migration in Keratinocyte. Molecules. 2020 Oct 12;25(20):4640. DOI:10.3390/molecules25204640 |
| | Beta-Neoendorphin Preparation Products And Raw materials |
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