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(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

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Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:(R)-2-Methyl-CBS-oxazaborolidine
CAS:112022-83-0
Purity:1.0M Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
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Products Intro: Product Name:(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
CAS:112022-83-0
Purity:99% Package:100g ,1KG ,5KG 25KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: Product Name:(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
CAS:112022-83-0
Purity:99% Package:25KG;5KG;1KG
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070
Email: product@chemlin.com.cn
Products Intro: CAS:112022-83-0
Package:g-Kg Remarks:Colorless to pale yellow liquid
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
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Email: sales03@shyrchem.com
Products Intro: Product Name:(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
CAS:112022-83-0
Purity:99% Package:0KG;0USD

(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole manufacturers

(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Basic information
Reactions
Product Name:(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
Synonyms:ALPHA,ALPHA-DIPHENYL-D-PROLINOL METHYLBORONIC ACID CYCL-AMIDE-ESTER;(R)-(+)-2-METHYL-CBS-OXAZABOROLIDINE;(R)-Methyloxazaborolidine,1-1.5Mintoluene[(R)-MeCBS]CoreyCatalyst;(r)-(+)-2-methyl-cbs-oxazaborolidine solution;(r)-2-methyl-cbs-oxazaborolidine, 1m soln. in toluene;α,α-diphenyl-d-prolinol methylboronic acid cycl-amide-ester;α,α-diphenyl-d-prolinolmethylboronic acid cyclamide ester;(R)-(+)-Methyl-CBS-oxazaborolidine
CAS:112022-83-0
MF:C18H20BNO
MW:277.17
EINECS:000-000-0
Product Categories:Asymmetric Synthesis;Chiral Catalysts, Ligands, and Reagents;Asymmetric Synthesis;B (Classes of Boron Compounds);B-Bromocatecholborane, etc.;Reduction;Synthetic Organic Chemistry;organic or inorganic borate
Mol File:112022-83-0.mol
(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Structure
(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Chemical Properties
Melting point 85-95 °C(lit.)
Boiling point 111 °C
density 0.95 g/mL at 25 °C
refractive index 68 ° (C=1, MeOH)
Fp 40 °F
storage temp. room temp
pka1.02±0.40(Predicted)
form Liquid
color Colorless to amber
optical activity[α]22/D +76.8°, c = 1 in toluene
Water Solubility Not miscible or difficult to mix in water.
Sensitive Air & Moisture Sensitive
BRN 9059874
Exposure limitsACGIH: TWA 20 ppm
OSHA: Ceiling 300 ppm; TWA 200 ppm
NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3)
InChIKeyVMKAFJQFKBASMU-QGZVFWFLSA-N
CAS DataBase Reference112022-83-0(CAS DataBase Reference)
Safety Information
Hazard Codes F,Xn,Xi
Risk Statements 11-38-48/20-63-65-67-36/37-19-40
Safety Statements 36/37-62-33-29-16-2-26
RIDADR UN 1294 3/PG 2
WGK Germany 3
10
HazardClass 3
PackingGroup II
HS Code 29319090
MSDS Information
(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Usage And Synthesis
Reactions
  1. Convenient catalyst for the enantioselective borane reduction of ketones at ambient temperatures.
  2. Asymmetric synthesis of α-chiral hydroxyalkylphosphines via a catalytic, enantioselective reduction of acylphosphines.
  3. Nickel-catalyzed cross-couplings of benzylic pivalates with arylboroxines: Stereospecific formation of diarylalkanes and triarylmethanes.
  4. Enantioselective reduction of prochiral ketones with NaBH4/Me2SO4/(S)-Me-CBS. 
Chemical Propertieswhite to light yellow crystal powde
UsesCBS Catalysts for Asymmetric Reduction and Asymmetric Synthesis
Uses(R)-2-Methyl-CBS-oxazaborolidine is used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2 symmetrical ferrocenyl diols, and propargyl alcohols. It is also used in a desymmetrizing reduction leading to (S)-4-hydroxycyclohexenone. It is useful in the production of stereospecific motifs such as α-hydroxy acids, α-amino acids, symmetrical ferrocenyl diols and propargyl alcohols.
Usessuzuki reaction
(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Preparation Products And Raw materials
Preparation Products4H-AMINO-6-BROMO-2,3-DIHYDROTHIOCHROMEN-1,1-DIOXIDE-->4-Hydroxy-6-bromo-2,3-dihydrothiochromen-1,1-dioxide-->(R)-alpha,alpha-Diphenylmethylprolinol
Tag:(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole(112022-83-0) Related Product Information
CATECHOLBORANE N-Benzylcinchonidinium chloride 2-{[(4-fluorophenyl)imino]methyl}phenol 2-Oxazolidinone, 3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-, (4S)-rel- 4-BENZOYLBUTYRIC ACID (4S)-3-(2,2-dimethylpropanoyl)-4-phenyl-1,3-oxazolidin-2-one 4a€-O-Benzyloxy (3S,4S)-Ezetimibe (R)-3-((S)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one EzetiMibe (3R,4R,3'S)-IsoMer ent-EzetiMibe Benzoic acid 2-Amino-2-methyl-1-propanol (3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one EzetiMibe ring-opening dehydrate iMpurity 3-O-Acetyl Ezetimibe ent-Ezetimibe Ketone Ezetimibe Impurity 82 Ezetimibe Impurity 36