(Rac)-Benpyrine manufacturers
- (Rac)-Benpyrine
-
- $67.00 / 1mg
-
2025-05-19
- CAS:1333714-43-4
- Min. Order:
- Purity: 98.55%
- Supply Ability: 10g
|
| | (Rac)-Benpyrine Basic information |
| Product Name: | (Rac)-Benpyrine | | Synonyms: | (Rac)-Benpyrine;4-((9H-Purin-6-yl)amino)-1-benzylpyrrolidin-2-one;autoimmune,Inhibitor,anti-inflammatory,(Rac) Benpyrine,(Rac)-Benpyrine,Tumor Necrosis Factor Receptor,IFN-γ,IL-1β,(Rac)Benpyrine,inhibit,TNF Receptor,IL-6,NF-κB,TNFR,TNF-α,IL-10;2-Pyrrolidinone, 1-(phenylmethyl)-4-(9H-purin-6-ylamino)-;Benpyrine racemate;(Rac)-Benpyrine, 10 mM in DMSO | | CAS: | 1333714-43-4 | | MF: | C16H16N6O | | MW: | 308.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1333714-43-4.mol |  |
| | (Rac)-Benpyrine Chemical Properties |
| Boiling point | 699.1±55.0 °C(Predicted) | | density | 1.456±0.06 g/cm3(Predicted) | | solubility | DMF: 1 mg/ml | | form | A solid | | pka | 10.01±0.10(Predicted) | | color | White to off-white |
| | (Rac)-Benpyrine Usage And Synthesis |
| Uses | (Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. | | in vivo | (Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction[1]. | Animal Model: | Kunming mice (7-8 weeks) treated with bovine type II collagen and a CFA complete adjuvant[1] | | Dosage: | 25 mg/kg, 50 mg/kg | | Administration: | Oral gavage; daily; for 3 weeks | | Result: | The inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum were obviously reduced, and the anti-inflammatory factor IL-10 was obviously increased.
|
| | References | [1] Hua Li, et al. Compound with TNF- α inhibitory activity and application. CN111320630A. |
| | (Rac)-Benpyrine Preparation Products And Raw materials |
|