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3-Isoquinolinecarboxylic acid, 6-[[(2S)-2-carboxy-4,4-difluoro-1-pyrrolidinyl]methyl]decahydro-, (3S,4aR,6S,8aR)-

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3-Isoquinolinecarboxylic acid, 6-[[(2S)-2-carboxy-4,4-difluoro-1-pyrrolidinyl]methyl]decahydro-, (3S,4aR,6S,8aR)- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:LY-466195；LY466195;LY 466195
CAS:317844-33-0
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:LY-466195
CAS:317844-33-0
Package:50mg;100mg;25mg
3-Isoquinolinecarboxylic acid, 6-[[(2S)-2-carboxy-4,4-difluoro-1-pyrrolidinyl]methyl]decahydro-, (3S,4aR,6S,8aR)- Basic information
Product Name:3-Isoquinolinecarboxylic acid, 6-[[(2S)-2-carboxy-4,4-difluoro-1-pyrrolidinyl]methyl]decahydro-, (3S,4aR,6S,8aR)-
Synonyms:LY-466195;3-Isoquinolinecarboxylic acid, 6-[[(2S)-2-carboxy-4,4-difluoro-1-pyrrolidinyl]methyl]decahydro-, (3S,4aR,6S,8aR)-;LY 466195;LY466195;LY466195,LY 466195
CAS:317844-33-0
MF:C16H24F2N2O4
MW:346.37
EINECS:
Product Categories:
Mol File:317844-33-0.mol
3-Isoquinolinecarboxylic acid, 6-[[(2S)-2-carboxy-4,4-difluoro-1-pyrrolidinyl]methyl]decahydro-, (3S,4aR,6S,8aR)- Structure
3-Isoquinolinecarboxylic acid, 6-[[(2S)-2-carboxy-4,4-difluoro-1-pyrrolidinyl]methyl]decahydro-, (3S,4aR,6S,8aR)- Chemical Properties
Boiling point 523.5±50.0 °C(Predicted)
density 1.37±0.1 g/cm3(Predicted)
pka1.38±0.40(Predicted)
Safety Information
MSDS Information
3-Isoquinolinecarboxylic acid, 6-[[(2S)-2-carboxy-4,4-difluoro-1-pyrrolidinyl]methyl]decahydro-, (3S,4aR,6S,8aR)- Usage And Synthesis
UsesLY-466195 is a selective and competitive GLUK5 receptor antagonist. LY-466195 antagonizes Kainate-induced currents with an IC50 value of 0.045 μM in rat dorsal root ganglion neurons. In HEK293 cells transfected with GLUK5, GLUK2/GLUK5, or GLUK5/GLUK66 receptors, LY466195 produces IC50 values of 0.08 μM, 0.34 μM, and 0.07 μM, respectively[1].
References[1] Brianne Weiss, et al. Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo. J Pharmacol Exp Ther. 2006 Aug;318(2):772-81. DOI:10.1124/jpet.106.101428
3-Isoquinolinecarboxylic acid, 6-[[(2S)-2-carboxy-4,4-difluoro-1-pyrrolidinyl]methyl]decahydro-, (3S,4aR,6S,8aR)- Preparation Products And Raw materials
Tag:3-Isoquinolinecarboxylic acid, 6-[[(2S)-2-carboxy-4,4-difluoro-1-pyrrolidinyl]methyl]decahydro-, (3S,4aR,6S,8aR)-(317844-33-0) Related Product Information
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