| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:GPX4-IN-2
CAS:2485005-22-7
Package:100mg/RMB 21500;25mg/RMB 12800;50mg/RMB 16800
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Tricyclo[3.3.1.13,7]decan-1-amine, N-[4-[(1S,3S)-3-butyl-1,2,3,4-tetrahydro-6-methoxy-1-isoquinolinyl]phenyl]- manufacturers
- GPX4-IN-2
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- $0.00 / 1removed
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2025-10-27
- CAS:2485005-22-7
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Tricyclo[3.3.1.13,7]decan-1-amine, N-[4-[(1S,3S)-3-butyl-1,2,3,4-tetrahydro-6-methoxy-1-isoquinolinyl]phenyl]- Basic information |
| Product Name: | Tricyclo[3.3.1.13,7]decan-1-amine, N-[4-[(1S,3S)-3-butyl-1,2,3,4-tetrahydro-6-methoxy-1-isoquinolinyl]phenyl]- | | Synonyms: | Tricyclo[3.3.1.13,7]decan-1-amine, N-[4-[(1S,3S)-3-butyl-1,2,3,4-tetrahydro-6-methoxy-1-isoquinolinyl]phenyl]-;GPX4-IN-2 | | CAS: | 2485005-22-7 | | MF: | C30H40N2O | | MW: | 444.65 | | EINECS: | | | Product Categories: | | | Mol File: | 2485005-22-7.mol | ![Tricyclo[3.3.1.13,7]decan-1-amine, N-[4-[(1S,3S)-3-butyl-1,2,3,4-tetrahydro-6-methoxy-1-isoquinolinyl]phenyl]- Structure](CAS/20210305/GIF/2485005-22-7.gif) |
| | Tricyclo[3.3.1.13,7]decan-1-amine, N-[4-[(1S,3S)-3-butyl-1,2,3,4-tetrahydro-6-methoxy-1-isoquinolinyl]phenyl]- Chemical Properties |
| Boiling point | 590.6±50.0 °C(Predicted) | | density | 1.109±0.06 g/cm3(Predicted) | | pka | 9.67±0.60(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | Tricyclo[3.3.1.13,7]decan-1-amine, N-[4-[(1S,3S)-3-butyl-1,2,3,4-tetrahydro-6-methoxy-1-isoquinolinyl]phenyl]- Usage And Synthesis |
| Uses | GPX4-IN-2 is a potent GPX4 inhibitor. GPX4 shows antiproliferative activity. GPX4-IN-2 has the potential for the research of cancer[1]. | | in vivo | GPX4-IN-2 (5 mg/kg for mouse, 2 mg/kg for rats; i.v.) shows a good pharmacokinetics profile in mice and rats[1]. | Animal Model: | 6-8 weeks, 22-25 g, Male Balb/c mice, 6-8 weeks, 200-250 g, male SD rats[1] | | Dosage: | 5 mg/kg for mouse, 2 mg/kg for rats | | Administration: | I.v. | | Result: | Showed a good pharmacokinetics with T1/2 of 3.5 h, Cmax of 5446 ng/mL, AUC of 1635 ng·h/mL, CL of 49 mL/min/kg, Vd of 14.7 L/kg in mice, T1/2 of 3.15 h, Cmax of 3529 ng/mL, AUC of 1082 ng·h/mL, CL of 30 mL/min/kg, Vd of 8.2 L/kg in rats. |
| | References | [1] Chun Jiang, et al. Compounds with ferroptosis inducing activity and methods of their use. WO2020176757A1. |
| | Tricyclo[3.3.1.13,7]decan-1-amine, N-[4-[(1S,3S)-3-butyl-1,2,3,4-tetrahydro-6-methoxy-1-isoquinolinyl]phenyl]- Preparation Products And Raw materials |
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