Letosteine manufacturers
- Letosteine
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- $2.00 / 1KG
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2020-01-09
- CAS:53943-88-7
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1kg, 5kg ,50kg
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| | Letosteine Basic information |
| Product Name: | Letosteine | | Synonyms: | 2-[2-(2-Ethoxy-2-oxoethyl)sulfanylethyl]-1,3-thiazolidine-4-carboxylic acid;4-Thiazolidinecarboxylic acid, 2-[2-[(2-ethoxy-2-oxoethyl)thio]ethyl]-;Viscotiol;Visoctiol;2-[2-[(2-Ethoxy-2-oxoethyl)thio]ethyl]-4-thiazolidinecarboxylic acid;Letosteine;2-(2-((2-ethoxy-2-oxoethyl)thio)ethyl)thiazolidine-4-carboxylic acid | | CAS: | 53943-88-7 | | MF: | C10H17NO4S2 | | MW: | 279.38 | | EINECS: | 258-879-3 | | Product Categories: | API | | Mol File: | 53943-88-7.mol |  |
| | Letosteine Chemical Properties |
| Melting point | 142° | | Boiling point | 470.0±45.0 °C(Predicted) | | density | 1.284±0.06 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Dichloromethane (Slightly), DMSO (Slightly) | | form | Solid | | pka | 2.05±0.40(Predicted) | | color | White to Pale Yellow | | CAS DataBase Reference | 53943-88-7 |
| | Letosteine Usage And Synthesis |
| Originator | Viscotiol,Carlo Erba,France,1979 | | Definition | ChEBI: A dicarboxylic acid monoester that is the monoethyl ester of 2-{2-[(carboxymethyl)sulfanyl]ethyl}-1,3-thiazolidine-4-carboxylic acid. A mucolytic used in the treatment of chronic bronchopneumopathies and related conditions. | | Manufacturing Process | In an Erlenmeyer flask placed in an ice bath, and under a well-ventilated
hood, a solution of 0.1 mol of acrolein in 100 ml of ether was introduced, With
the aid of a bromine ampoule, 0.1 mol (= 11 ml) of the ethyl ester of
thioglycolic acid containing 0.5 ml of triethylamine was added drop by drop.
One hour after completion of the addition, there was added 0.1 mol (15.6 g)
of chlorhydrate of cysteine in alcoholic solution. The chlorhydrate of the
expected derivative, which appeared in the form of a thick oil, was
precipitated by addition of 0.1 mol (10 g) of potassium acetate in aqueous
solution. The abundant precipitate obtained was filtered and washed in water
and ether. The product was recrystallized in a minimum of absolute alcohol. | | Therapeutic Function | Mucolytic |
| | Letosteine Preparation Products And Raw materials |
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