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Product Name:2S,4R-Sacubitril
CAS:2307668-79-5
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| | 2S,4R-Sacubitril Basic information |
| Product Name: | 2S,4R-Sacubitril | | Synonyms: | [1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxobutyl)amino]-α-methyl-, 4-ethyl ester, (αR,γS)-rel- | | CAS: | 2307668-79-5 | | MF: | C25H31NO5 | | MW: | 425.53 | | EINECS: | | | Product Categories: | | | Mol File: | 2307668-79-5.mol |  |
| | 2S,4R-Sacubitril Chemical Properties |
| Boiling point | 658.5±55.0 °C(Predicted) | | density | 1.136±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 4.76±0.10(Predicted) |
| | 2S,4R-Sacubitril Usage And Synthesis |
| Description | 2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure. | | References | [1]. Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9. |
| | 2S,4R-Sacubitril Preparation Products And Raw materials |
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