| Company Name: |
Finetech Industry Limited
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| Tel: |
027-87465837 19945049750 |
| Email: |
sales@finetechnology-ind.com |
| Products Intro: |
Product Name:Dhodh-IN-16
CAS:2511248-11-4
Purity:98% Package:1g,10g,25g,500g,1kg
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| | Dhodh-IN-16 Basic information |
| Product Name: | Dhodh-IN-16 | | Synonyms: | 6-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-7-fluoro-4-isopropyl-2-(o-tolyl)isoquinolin-1(2H)-one;DHODH-IN-16;DNA/RNA Synthesis,inhibit,Dihydroorotate Dehydrogenase,Inhibitor,antiproliferative,DHODH IN 16,DHODH,DHODHIN16;1(2H)-Isoquinolinone, 6-[4-ethyl-4,5-dihydro-3-(hydroxymethyl)-5-oxo-1H-1,2,4-triazol-1-yl]-7-fluoro-4-(1-methylethyl)-2-(2-methylphenyl)- | | CAS: | 2511248-11-4 | | MF: | C24H25FN4O3 | | MW: | 436.48 | | EINECS: | | | Product Categories: | | | Mol File: | 2511248-11-4.mol |  |
| | Dhodh-IN-16 Chemical Properties |
| Boiling point | 602.6±65.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (229.11 mM; Need ultrasonic) | | pka | 13.54±0.10(Predicted) |
| | Dhodh-IN-16 Usage And Synthesis |
| Biological Activity | DHODH-IN-16 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH[1].
DHODH-IN-16 (Example 22) potently inhibits the growth of MOLM-13 cells with an IC50 of 0.2 nM[1]. | | References | [1]. Scott Kuduk, et al. Dihydroorotate dehydrogenase inhibitors. WO2020212897A1. |
| | Dhodh-IN-16 Preparation Products And Raw materials |
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