|
| 4-Amino-1-benzylpiperidine Basic information |
| 4-Amino-1-benzylpiperidine Chemical Properties |
Melting point | 121-122 °C(Solv: water (7732-18-5); ethanol (64-17-5)) | Boiling point | 152 °C (9.7 mmHg) | density | 0.933 g/mL at 25 °C (lit.) | refractive index | n20/D 1.543(lit.) | Fp | >230 °F | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | solubility | 10g/l | form | Liquid | pka | 10.15±0.20(Predicted) | color | Clear colorless to light yellow | PH | 11.4 (10g/l, H2O) | Water Solubility | immiscible | Sensitive | Air Sensitive | BRN | 146038 | InChIKey | YUBDLZGUSSWQSS-UHFFFAOYSA-N | CAS DataBase Reference | 50541-93-0(CAS DataBase Reference) |
| 4-Amino-1-benzylpiperidine Usage And Synthesis |
Chemical Properties | clear colourless to light yellow liquid | Uses | 4-Amino-1-benzylpiperidine was used in the preparation of:
- butyl 4-amino-1-piperidineacetate, key intermediate required for the synthesis of butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate
- 5-alkylimino-1,2,4-thiadiazolidine-3-ones, such as 4-ethyl-5-[imino-[1-(phenylmethyl)-4-piperidinyl]]-2-methyl-1,2,4-thiadiazolidin-3-one and 4-benzyl-5-[imino-[1-(phenylmethyl)-4-piperidinyl]]-2-isopropyl-1,2,4-thiadiazolidin-3-one
- glycyrrhetinic acid derivatives
| Purification Methods | Purify it by distillation in vacuo and store it under N2 because it absorbs CO2. The dihydrochloride salt [1205-72-7] has m 270-273o (255o) after recrystallisation from MeOH/EtOAc or EtOH. [Brookes J Chem Soc 3165, 3172 1957.] The 4-methylamino-1-benzylpiperidine derivative has b 168-172o/17mm, nD 1.5367 [Reitsema & Hunter J Am Chem Soc 70 4009 1948]. The 1-(1-benzyl-4-piperidinyl)-3-cyano-2-methylisothiourea derivative has m 160o from CHCl3/Et2O [Preparation, IR, NMR: Ried et al. Chem Ber 116 1547 1983, Beilstein 22 III/IV 3752]. |
| 4-Amino-1-benzylpiperidine Preparation Products And Raw materials |
|